52834-09-0

Basic information

• Product Name: 4-Amino-5-chloronicotinic acid
• Synonyms: 4-AMINO-5-CHLORO NICOTINIC ACID;4-amino-5-chloro-3-Pyridinecarboxylic acid
• CAS NO: 52834-09-0
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.57
• Product Categories: Pyridine
• Mol File: 52834-09-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 371.5 °C at 760 mmHg
• Flash Point: 178.5 °C
• Appearance: /
• Density: 1.577 g/cm³
• Vapor Pressure: 3.54E-06mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: 2-8°C
• PKA: 2.57±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-5-chloronicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-5-chloronicotinic acid(52834-09-0)
• EPA Substance Registry System: 4-Amino-5-chloronicotinic acid(52834-09-0)

Safety Data

• Hazardous Substances Data: 52834-09-0(Hazardous Substances Data)

Usage

General Description

4-Amino-5-chloronicotinic acid is a chemical compound with the molecular formula C6H5ClNO2. It is a derivative of nicotinic acid and contains both an amino group and a chlorine atom. 4-Amino-5-chloronicotinic acid is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. Its properties and structure make it a versatile starting material for the development of novel drugs and agrochemicals. Additionally, 4-Amino-5-chloronicotinic acid has potential applications in the field of materials science and can be used as a precursor for the synthesis of functionalized materials.

InChI:InChI=1/C6H5ClN2O2/c7-4-2-9-1-3(5(4)8)6(10)11/h1-2H,(H2,8,9)(H,10,11)

Upstream product

• 7418-65-7 4-aminonicotinic acid 
• 1073182-72-5 4-tert-butoxycarbonylamino-5-chloro-nicotinic acid 
• 108554-34-3 methyl 4-oxonipecotate 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 

Relevant articles and documents

Preparation method of nicotinic acid derivative

The invention relates to a preparation method of a nicotinic acid derivative. The method comprises the following steps: with N-benzylpiperidine-4-keto-3-formate as a raw material, carrying out a hydrogenolysis reaction to obtain piperidine-4-keto-3-formate; performing halogenation reaction with a certain amount of a halogenation reagent to obtain 3,5-dihalogenated piperidine-4-one-3-formate or 3,5,5-trihalogenated piperidine-4-one-3-formateperforming one-pot process with different alkaline reagent for removing halogen hydride through elimination, and performing hydrolysis and performing acidification with hydrochloric to generate corresponding nicotinic acid derivatives: 4-hydroxynicotinic acid, 4-aminonicotinic acid, 4-hydroxy-5-chloronicotinic acid, 4-amino-5-chloronicotinic acid and 4-amino-5-bromonicotinic acid. The method is simple and convenient to operate, mild in condition, short in technological process, low in wastewater amount, environmentally friendly and low in cost, and green industrial production of the nicotinic acid derivative is facilitated.

Inhibiting the growth of weeds with 2-substituted pyrdidopyimidines and salts thereof

2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.