52941-82-9Relevant articles and documents
Method for synthesizing 1,3-dihydroxyacetone through indirect oxidation of glycerol
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Paragraph 0025; 0026; 0029; 0031; 0033; 0035; 0037; 0039, (2019/04/18)
The invention relates to a method for synthesizing 1,3-dihydroxyacetone through indirect oxidation of glycerol, the method comprises the following steps: carrying out an acetalation reaction, to be more specific, an organic solvent is used as a water-carrying agent, glycerol and benzaldehyde are subjected to acetalation reaction under the action of a solid acid catalyst to obtain 2-phenyl-5-hydroxy-1,3-dioxane (HPD); oxidizing reaction, to be more specific, in an organic solvent, the 2-phenyl-5-hydroxy-1,3-dioxane (HPD) is oxidized into 2-phenyl-5-carbonyl-1,3-dioxane (PDO) by an oxidizing agent under the action of a liquid catalyst and auxiliary agent sodium bromide; hydrolysis reaction, to be more specific, the 2-phenyl-5-carbonyl-1,3-dioxane (PDO) is subjected to hydrolysis reaction under the action of a liquid acid catalyst to obtain a target product. The synthetic process route takes the glycerol as a raw material, the selectivity and the yield are higher than that of the direct oxidation method, the target product is simple in separation, the purity of the product is up to 99%, and industrial production is facilitated.
Magnetic Polystyrene Nanosphere Immobilized TEMPO: A Readily Prepared, Highly Reactive and Recyclable Polymer Catalyst in the Selective Oxidation of Alcohols
Zheng, Zhi,Wang, Jianli,Zhang, Miao,Xu, Lixin,Ji, Jianbing
, p. 307 - 312 (2013/03/13)
The 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical immobilized on the magnetic polystyrene nanospheres (MPNs) was used as a recyclable catalyst in the oxidation of various alcohols. The new and simply prepared heterogeneous TEMPO/MPNs exhibits both similar versatility and efficiency to homogeneous TEMPO under basic Montanari conditions. The excellent stability of the MPNs enables the TEMPO/MPNs to be recycled more than 20times without significant leaching of immobilized TEMPO radicals or degradation of Fe3O4 nanoparticles. Moreover, the magnetic response ensures the rapid separation and quantitative recycling of TEMPO/MPNs by simple magnetic decantation.
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols
Tewes, Bastian,Frehland, Bastian,Schepmann, Dirk,Schmidtke, Kai-Uwe,Winckler, Thomas,Wünsch, Bernhard
supporting information; experimental part, p. 8005 - 8015 (2011/02/23)
NR2B selective NMDA receptor antagonists with tetrahydro-3-benzazepine-1,7- diol scaffold have been designed by formal cleavage and reconstitution of the piperidine ring of the lead compound ifenprodil (1). The secondary amine 10 represents the central bu