53056-20-5

Basic information

• Product Name: (2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE
• Synonyms: (2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE;2,4-dichlorobenzeneacetyl chloride;Dichlorophenylacetyl Chloride;2-(2,4-dichlorophenoxy)ethanoyl chloride;2,4-dichloro-phenyl chloride;2-(2,4-dichlorophenyl)acetyl chloride
• CAS NO: 53056-20-5
• Molecular Formula: C₈H₅Cl₃O
• Molecular Weight: 223.48
• EINECS: 1806241-263-5
• Mol File: 53056-20-5.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 286.8 °C at 760 mmHg
• Flash Point: 119.7 °C
• Appearance: /
• Density: 1.445 g/cm³
• Vapor Pressure: 0.00258mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: (2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE(53056-20-5)
• EPA Substance Registry System: (2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE(53056-20-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53056-20-5(Hazardous Substances Data)

Usage

General Description

(2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE is a chemical compound with the molecular formula C8H6Cl2O. It is a chlorinated acetyl chloride with a 2,4-dichlorophenyl group attached. (2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE is commonly used in organic synthesis as a reagent for the acetylation of various compounds. It is also used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. (2,4-DICHLORO-PHENYL)-ACETYL CHLORIDE is a highly reactive and corrosive compound that requires careful handling and storage.

InChI:InChI=1/C8H5Cl3O/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4H,3H2

Upstream product

• 106-46-7 para-dichlorobenzene 
• 79-04-9 chloroacetyl chloride 
• 19719-28-9 2,4-dichlorophenylacetic acid 
• 6306-60-1 2,4-Dichlorophenylacetonitrile 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 1777-82-8 (2,4-dichlorophenyl)methanol 
• 20443-99-6 2,4-dichlorobenzyl bromide 

Downstream Products

• 19062-25-0 2-(2,4-Dichloro-phenyl)-N,N-bis-[2-(2,4-dichloro-phenyl)-ethyl]-acetamide 
• 153529-19-2 2-(2,4-dichlorophenyl)-1-(4-methoxyphenyl)ethanone 
• 107680-34-2 2-(2,4-dichlorophenyl)-2',4'-dichloroacetophenone 
• 98617-95-9 2-(2,4-Dichloro-phenyl)-1-(4-fluoro-phenyl)-ethanone 
• 188848-22-8 2-(2,4-Dichloro-phenyl)-1-thiophen-2-yl-ethanone 
• 188848-27-3 2-(2,4-Dichloro-phenyl)-1-(5-methyl-thiophen-2-yl)-ethanone 
• 188848-33-1 2-(2,4-Dichloro-phenyl)-1-(1-methyl-1H-pyrrol-3-yl)-ethanone 
• 188848-30-8 2-(2,4-Dichloro-phenyl)-1-(1-methyl-1H-pyrrol-2-yl)-ethanone 
• 188848-24-0 1-(5-Chloro-thiophen-2-yl)-2-(2,4-dichloro-phenyl)-ethanone 
• 366456-21-5 N-(2-benzoyl-4-nitrophenyl)-2-(2,4-dichlorphenyl)acetamide 
• 19654-32-1 2,4-dichloro-1-(isocyanatomethyl)benzene 
• 361366-16-7 1-[2-(2,4-Dichloro-phenyl)-acetoxy]-cyclohexanecarboxylic acid ethyl ester 

Relevant articles and documents

Pentuline derivatives and preparation methods and applications thereof

The present invention provides a chingotine derivative, the structural formula of which is shown in formula I. Specifically, the R is any of the following groups: p-chlorophenylacetyl, 2,4-dichlorophenylacetyl, m-chlorophenylacetyl, 3,4-dichlorophenylacet

Design, synthesis, biological evaluation and silico prediction of novel sinomenine derivatives

Sinomenine is a morphinan alkaloid with a variety of biological activities. Its derivatives have shown significant cytotoxic activity against different cancer cell lines in many studies. In this study, two series of sinomenine derivatives were designed and synthesized by modifying the active positions C1 and C4 on the A ring of sinomenine. Twenty‐three compounds were synthesized and characterized by spectroscopy (IR,1H‐NMR,13C‐NMR, and HRMS). They were further evaluated for their cytotoxic activity against five cancer cell lines, MCF‐7, Hela, HepG2, SW480 and A549, and a normal cell line, Hek293, using MTT and CCK8 methods. The chlorine‐containing compounds exhibited significant cytotoxic activity compared to the nucleus structure of sinomenine. Furthermore, we searched for cancer‐related core targets and verified their interaction with derivatives through molecular docking. The chlorine‐containing compounds 5g, 5i, 5j, 6a, 6d, 6e, and 6g exhibited the best against four core targets AKT1, EGFR, HARS and KARS. The molecular docking results were consistent with the cytotoxic results. Overall, results indicate that chlorine‐containing derivatives might be a promising lead for the development of new anticancer agents.

Quantitative activity-activity relationship (QAAR) driven design to develop hydroxamate derivatives of pentanoic acids as selective HDAC8 inhibitors: synthesis, biological evaluation and binding mode of interaction studies

Histone deacetylase 8 (HDAC8) has been implicated as a potential drug target of many diseases including cancer. HDAC8 isoform selectivity over other class-I HDACs is a major concern nowadays. In this work, a series of pentanoic acid based hydroxamates wit