53090-43-0

Basic information

• Product Name: 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;ETHYL 3-(3,4-DICHLOROPHENYL)-3-OXOPROPANOATE;ETHYL (3,4-DICHLOROBENZOYL)ACETATE;Ethyl 2-(3,4-dichlorobenzoyl)acetate;Ethyl 3-(3,4-dichlorophenyl)-3-oxopropionate
• CAS NO: 53090-43-0
• Molecular Formula: C₁₁H₁₀Cl₂O₃
• Molecular Weight: 261.1
• Mol File: 53090-43-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 357.6°C at 760 mmHg
• Flash Point: 147.2°C
• Appearance: /
• Density: 1.319
• Vapor Pressure: 2.7E-05mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.62±0.48(Predicted)
• CAS DataBase Reference: 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(53090-43-0)
• EPA Substance Registry System: 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(53090-43-0)

Safety Data

• Hazardous Substances Data: 53090-43-0(Hazardous Substances Data)

Usage

General Description

3-(3,4-Dichloro-phenyl)-3-oxo-propionic acid ethyl ester is a chemical compound with the molecular formula C11H10Cl2O3. It is an ethyl ester derivative of 3-(3,4-dichlorophenyl)-3-oxo-propanoic acid and is commonly used in organic synthesis and medicinal chemistry. 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is a yellowish-brown solid that is slightly soluble in water and has a characteristic odor. It is used in the production of pharmaceutical drugs and in the research and development of new chemical compounds. It is important to handle 3-(3,4-dichloro-phenyl)-3-oxo-propionic acid ethyl ester with caution, as it may pose hazards to human health and the environment.

InChI:InChI=1/C11H10Cl2O3/c1-2-16-11(15)6-10(14)7-3-4-8(12)9(13)5-7/h3-5H,2,6H2,1H3

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 3024-72-4 3,4-dichlorobenzoyl chloride 
• 6148-64-7 ethyl potassium malonate 
• 51-44-5 3,4-dichlorbenzoic acid 
• 2642-63-9 3',4'-dichloroacetophenone 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 98305-86-3 2-Amino-6-(3,4-dichloro-phenyl)-3H-pyrimidin-4-one 
• 1027729-45-8 3-(3,4-dichloro-phenyl)-3,3-diethoxy-propionic acid ethyl ester 
• 191673-26-4 3-(3,4-dichlorophenyl)-3-oxo-1-propanol 
• 191673-28-6 3-(3,4-dichlorophenyl)-3-oxo-l-propanol tert-butyldimethylsilyl ether 
• 76519-33-0 2-Amino-5-chloro-6-(3,4-dichloro-phenyl)-3H-pyrimidin-4-one 
• 76519-18-1 2-Amino-5-bromo-6-(3,4-dichloro-phenyl)-3H-pyrimidin-4-one 
• 76519-19-2 2-Amino-6-(3,4-dichloro-phenyl)-5-iodo-3H-pyrimidin-4-one 
• 1399840-67-5 (E)-ethyl 2-(3,4-dichlorobenzoyl)-6-hydroxyhex-4-enoate 
• 1399840-90-4 (E)-ethyl 2-(3,4-dichlorobenzoyl)-6-oxohex-4-enoate 
• 1399841-07-6 (1S,4R,5S)-ethyl 5-(3,4-dichlorophenyl)-7-oxo-6-oxabicyclo[3.2.0]heptane-4-carboxylate 
• 1184849-00-0 (1R)-2-{[2-cyclopropyl-6-(3,4-dichlorophenyl)pyrimidin-4-yl]amino}-1-phenylethanol 
• 1184850-57-4 4-chloro-2-cyclopropyl-6-(3,4-dichloro-phenyl)-pyrimidine 
• 1184850-56-3 2-cyclopropyl-6-(3,4-dichloro-phenyl)-pyrimidin-4-ol 
• 1607023-54-0 5-(3,4-dichlorophenyl)-3-(4-methylthiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 

Relevant articles and documents

Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex

Starting from our previously reported hit, a series of 1,5-diaryl-1,2,3-triazole-4-carbohydrazones were synthesized and evaluated as inhibitors of the YAP/TAZ-TEAD complex. Their binding to hTEAD2 was confirmed by nanodifferential scanning fluorimetry, an

Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights

A rhodium-catalyzed denitrogenative formal (3 + 3) transannulation of 1,2,3-thiadiazoles with alk-2-enals is achieved, producing 2,3-dihydrothiopyran-4-ones in moderate to excellent yields. An inverse KIE of 0.49 is obtained, suggesting the reversibility of the oxidative addition of thioacyl Rh(i) carbenes to alk-2-enals. The late-stage structural modifications of steroid compounds are realized. Moreover, our studies show that thioacyl carbenes have different reactivities to those of α-oxo and α-imino carbenes, and highlight the importance of heteroatoms in deciding the reactivities of heterovinyl carbenes.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.