53104-96-4

Basic information

• Product Name: 2-(DIFLUOROMETHOXY)PHENOL 98
• Synonyms: 2-(DIFLUOROMETHOXY)PHENOL 98;2-(Difluoromethoxy)phenol 98%
• CAS NO: 53104-96-4
• Molecular Formula: C₇H₆F₂O₂
• Molecular Weight: 160.1184
• Mol File: 53104-96-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 196.7 °C at 760 mmHg
• Flash Point: 99.1 °C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 0.28mmHg at 25°C
• Refractive Index: 1.481
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.71±0.30(Predicted)
• CAS DataBase Reference: 2-(DIFLUOROMETHOXY)PHENOL 98(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIFLUOROMETHOXY)PHENOL 98(53104-96-4)
• EPA Substance Registry System: 2-(DIFLUOROMETHOXY)PHENOL 98(53104-96-4)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 45
• Hazardous Substances Data: 53104-96-4(Hazardous Substances Data)

Usage

Description

2-(DIFLUOROMETHOXY)PHENOL 98 is an organic compound characterized by the presence of a difluoromethoxy group attached to a phenol molecule. This chemical structure endows it with unique properties that make it suitable for various applications, particularly in the synthesis of other compounds.

Uses

Used in Pharmaceutical Industry:
2-(DIFLUOROMETHOXY)PHENOL 98 is used as a reactant in the synthesis of 3-methoxy-2-(pyrimidinyloxyphenyl)acrylates, which are a class of pesticides. These pesticides are employed to control pests and protect crops, ensuring higher yields and better quality produce.
Used in Chemical Synthesis:
2-(DIFLUOROMETHOXY)PHENOL 98 is utilized as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique difluoromethoxy group allows for the development of novel compounds with specific properties and applications.

InChI:InChI=1/C7H6F2O2/c8-7(9)11-6-4-2-1-3-5(6)10/h1-4,7,10H

Upstream product

• 1717-59-5 2,2-difluoro-2-(fluorosulfonyl)acetic acid 
• 120-80-9 benzene-1,2-diol 
• 6272-38-4 O-benzylcatechol 

Downstream Products

• 1257072-89-1 2-(difluoromethoxy)-6-nitrophenol 

Relevant articles and documents

1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS

A compound of formula (I), wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

A SIMPLE CONVENIENT METHOD FOR PREPARATION OF DIFLUOROMETHYL ETHERS USING FLUOROSULFONYLDIFLUOROACETIC ACID AS A DIFLUOROCARBENE PRECURSOR

In the presence of catalytic amounts of sodium sulfate or cuprous iodide, a variety of alkyl and aryl difluoromethyl ethers were synthesized in moderate yields by the reaction of the corresponding alcohols and phenols with fluorosulfonyldifluoroacetic acid (1) in acetonitrile under mild conditions.Fluorosulfonyldifluoroacetate anion (5) is believed to readily eliminate SO2, CO2 and F(1-), thus liberating CF2:; insertion of difluorocarbene into O-H bonds and its capture by fluorode ion then result in the formation of ethers and by-product CF3H, respectively.

Picoline derivative useful as gastric acid secretion inhibitors

Picoline derivatives of the formula I STR1 wherein the substituents have the meanings given in the description, and their salts are new compounds having a pronounced protective action on the stomach.