53171-39-4

Basic information

• Product Name: METHYL SUCCINAMATE
• Synonyms: SUCCINAMIC ACID METHYL ESTER;METHYL SUCCINAMATE
• CAS NO: 53171-39-4
• Molecular Formula: C₅H₉NO₃
• Molecular Weight: 131.13
• Mol File: 53171-39-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 89 °C
• Boiling Point: 118 °C / 3mmHg
• Flash Point: 179.5 °C
• Appearance: /
• Density: 1.136 g/cm³
• Vapor Pressure: 0.00134mmHg at 25°C
• Refractive Index: 1.442
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 15.91±0.40(Predicted)
• CAS DataBase Reference: METHYL SUCCINAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL SUCCINAMATE(53171-39-4)
• EPA Substance Registry System: METHYL SUCCINAMATE(53171-39-4)

Safety Data

• Hazardous Substances Data: 53171-39-4(Hazardous Substances Data)

Usage

Description

METHYL SUCCINAMATE, a synthetic intermediate, is a chemical compound that plays a significant role in the synthesis of various pharmaceuticals and other applications. It is characterized by its ability to be transformed into different compounds, making it a versatile building block in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
METHYL SUCCINAMATE is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its primary application is in the synthesis of substituted oxazole-benzamide antibacterial inhibitors of FtsZ, which are essential in the fight against bacterial infections.

InChI:InChI=1/C5H9NO3/c1-9-5(8)3-2-4(6)7/h2-3H2,1H3,(H2,6,7)

Upstream product

• 123-56-8 Succinimide 
• 67-56-1 methanol 
• 872805-52-2 3-carbamoyl-orthopropionic acid trimethyl ester 
• 4107-62-4 3-cyano-propionic acid methyl ester 
• 1490-25-1 succinic acid monomethylester chloride 
• 106-65-0 Dimethyl succinate 
• 74-88-4 methyl iodide 
• 638-32-4 succinamic acid 

Downstream Products

• 123-56-8 Succinimide 
• 77300-42-6 3-(Methoxycarbonylamino)propionsaeure-methylester 
• 936850-80-5 3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propionic acid methyl ester 
• 1051372-53-2 methyl 3-(4-(2-fluorophenyl)oxazol-2-yl)propanoate 
• 1252657-91-2 methyl 3-{4-[3,5-bis(trifluoromethyl)phenyl]-1,3-oxazol-2-yl}propanoate 
• 1374746-29-8 C₁₀H₁₈N₂O₃ 
• 100517-28-0 N,N'-carbonyl-di-β-alanine dimethyl ester 
• 1249098-65-4 C₈H₁₆N₂O₃ 
• 1374746-30-1 C₁₁H₂₂N₂O₃ 

Relevant articles and documents

DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES

The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.

FUSED HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.

Selective ammonolysis and aminolysis of dimethyl succinate. Synthesis of optically active N-alkylsuccinimides

Candida antarctica lipase catalyzes the selective monoammonolysis and aminolysis of dimethyl succinate with ammonia and aliphatic amines, respectively, in dioxane as solvent. This enzyme shows a high enantioselectivity when racemic amines are used. Optically active amidoesters are also obtained in the reaction of dimethyl succinate with racemic α-methylalkylamines in hexane as solvent. In this medium, the enzyme catalyzes the formation of N-alkylsuccinimides or optically active N-alkyl-α-methylsuccinimides from dimethyl succinate or α-methylsuccinate and amines.