532-27-4

Basic information

• Product Name: 2-Chloroacetophenone
• Synonyms: Acetophenone,2-chloro- (8Cl);Acetophenone, a-chloro- (3Cl);(2-Chloro-1-oxoethyl)benzene;(Chloroacetyl)benzene;1-Phenyl-2-chloro-1-ethanone;2-Chloro-1-phenyl-1-ethanone;2-Chloro-1-phenylethanone;α-Chloroacetophenone;w-Chloroacetophenone;Benzoylmethyl chloride;a-Chloroacetophenone;Phenyl chloromethyl ketone;Phenacylchloride;NSC 41666;Chloromethyl phenyl ketone
• CAS NO: 532-27-4
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 154.59358
• EINECS: 208-531-1
• Mol File: 532-27-4.mol
• Article Data: 182

Chemical Properties

• Melting Point: 52-56℃
• Boiling Point: 244.5 °C at 760 mmHg
• Flash Point: 104.8 °C
• Appearance: White to light yellow crystal
• Density: 1.168 g/cm³
• Refractive Index: 1.5438
• Water Solubility: insoluble. <0.1 g/100 mL at 19℃
• CAS DataBase Reference: 2-Chloroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloroacetophenone(532-27-4)
• EPA Substance Registry System: 2-Chloroacetophenone(532-27-4)

Safety Data

• Hazard Codes: T:Toxic
• Statements: R23/25:; R36/37/38:
• Safety Statements: S26:; S28A:; S36/37/39:; S45:
• Hazardous Substances Data: 532-27-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2

Upstream product

• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 
• 98-88-4 benzoyl chloride 
• 109538-22-9 diethyl-(1,2-dichloro-vinyl)-amine 
• 107-14-2 chloroacetonitrile 
• 94-41-7 benzalacetophenone 
• 79-04-9 chloroacetyl chloride 
• 71-43-2 benzene 
• 56-23-5 tetrachloromethane 
• 624-85-1 ethyl hypochlorite 
• 98-86-2 acetophenone 
• 3135-74-8 chlorourea 
• 1674-30-2 1-phenyl-2-chloroethanol 
• 919-24-4 tetrakis(chloroacetoxy)silane 

Downstream Products

• 1005-91-0 2-phenyl-2-(chloromethyl)oxirane 
• 779-52-2 1-phenyl-2-piperidin-1-yl-ethanone 
• 115217-25-9 2-hexahydroazocin-1-yl-1-phenyl-ethanone 
• 20517-71-9 1-(2-oxo-2-phenylethyl)pyridin-1-ium chloride 
• 108924-89-6 3-hydroxy-1-phenacyl-pyridinium; chloride 
• 40327-64-8 (3-furan-2-yl-oxiranyl)-phenyl-methanone 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 885-89-2 8-methyl-2-phenylimidazo[1,2-a]pyridine 
• 111733-88-1 2-(1-hexamethyleneimino)acetophenone 
• 14384-67-9 4-phenyl-2-(2-pyridyl)thiazole 
• 193688-13-0 2-benzoylbenzothiophene-3-carboxylic acid 
• 49864-67-7 5-phenacyloxy-2-hydroxymethyl-4-pyrone 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 

Relevant articles and documents

Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks

α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of β-chloroamines and indoles.

Mild oxidation of benzyl alcohols to benzyl aldehydes or ketones catalyzed by visible light

Induced by visible light, mild oxidation condition to prepare benzyl aldehydes or ketones have been developed by using bromotrichloromethane as photochemical oxidant. This method avoids high temperature, pressure and peroxidation with only visible light as the green driving force.

Tris-(2-pyridylmethyl)amine-ligated Cu(II) 1,3-diketonate complexes: Anaerobic retro-Claisen and dehalogenation reactivity of 2-chloro-1,3-diketonate derivatives

We report synthetic, structural and reactivity investigations of tris-(2-pyridylmethyl)amine (TPA)-ligated Cu(ii) 1,3-diketonate complexes. These complexes exhibit anaerobic retro-Claisen type C-C bond cleavage reactivity which exceeds that found in analo