5320-98-9

Basic information

• Product Name: 4-(O-NITROPHENYL)MORPHOLINE
• Synonyms: 4-(O-NITROPHENYL)MORPHOLINE;1-Morpholino-2-nitrobenzene;Ai3-14927;Brn 0195817;Morpholine, 4-(2-nitrophenyl)-;Morpholine, 4-(o-nitrophenyl)-;2-(Morpholin-4-yl)nitrobenzene
• CAS NO: 5320-98-9
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.21388
• Mol File: 5320-98-9.mol
• Article Data: 36

Chemical Properties

• Melting Point: 40-41 °C
• Boiling Point: 357.7°Cat760mmHg
• Flash Point: 170.1°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 2.68E-05mmHg at 25°C
• Refractive Index: 1.577
• PKA: 2.75±0.40(Predicted)
• CAS DataBase Reference: 4-(O-NITROPHENYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(O-NITROPHENYL)MORPHOLINE(5320-98-9)
• EPA Substance Registry System: 4-(O-NITROPHENYL)MORPHOLINE(5320-98-9)

Safety Data

• Hazardous Substances Data: 5320-98-9(Hazardous Substances Data)

Usage

Description

4-(O-NITROPHENYL)MORPHOLINE is an organic compound that features a morpholine ring with a nitrophenyl group attached to it. It is known for its chemical reactivity and is commonly utilized in various chemical synthesis processes.

Uses

Used in Chemical Synthesis:
4-(O-NITROPHENYL)MORPHOLINE is used as a reactant for [application reason] in the palladium-catalyzed amination of aryl nonaflates. This application takes advantage of its reactivity to facilitate the formation of new chemical bonds and create a range of products in the field of organic chemistry.
If there are different applications in different industries, they are listed separately:
Used in Pharmaceutical Industry:
4-(O-NITROPHENYL)MORPHOLINE is used as an intermediate for [application reason] in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a valuable building block in the development of new drugs and medications.
Used in Research and Development:
4-(O-NITROPHENYL)MORPHOLINE is used as a research compound for [application reason] in the exploration of new chemical reactions and mechanisms. It serves as a useful tool for scientists to study and understand the behavior of different chemical groups and their interactions with other molecules.

InChI:InChI=1/C10H12N2O3/c13-12(14)10-4-2-1-3-9(10)11-5-7-15-8-6-11/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 577-19-5 2-nitrophenyl bromide 
• 609-73-4 o-nitroiodobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 132993-22-7 2-nitrophenyl trifluoromethanesulfonate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 342589-38-2 2-nitrophenyl nonaflate 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 13368-42-8 4-(trimethylsilyl)morpholine 
• 88-75-5 2-hydroxynitrobenzene 
• 58534-94-4 2-fluoro-3-bromonitrobenzene 
• 874480-23-6 C₁₂H₈N₂O₄Zn 
• 15163-59-4 potassium o-nitrobenzoate 
• 17264-82-3 sodium 2-nitrobenzoate 

Downstream Products

• 5585-33-1 2-morpholinoaniline 
• 27386-34-1 3,4-dihydro-1H-benzo[4,5]imidazo[2,1-c][1,4]oxazine 10-oxide 
• 78019-83-7 N-(2-nitrophenyl)-morpholine N-oxide 
• 338949-23-8 1-(2-nitrophenyl)morpholine-2-carbonitrile 
• 78019-99-5 4-(2-Nitro-phenoxy)-morpholine 
• 400076-83-7 2-chloro-N-(2-morpholinophenyl)nicotinamide 
• 5638-73-3 3,4-dihydro-1H-benzo[4,5]imidazo[2,1-c][1,4]oxazine 
• 1173462-16-2 phenyl (2-morpholinophenyl)carbamate 

Relevant articles and documents

Palladium nanoparticles supported on cysteine-functionalized MNPs as robust recyclable catalysts for fast O- and N-arylation reactions in green media

A magnetically robust recyclable nanocatalyst was fabricated by immobilizing of Pd onto the surface of cysteine-functionalized magnetic nanoparticles (MNPs?Cys-Pd). This nanocatalyst was characterized using various techniques such as FT-IR, XRD, TEM, SEM, EDX, VSM, and ICP. The application of catalyst (MNPs?Cys-Pd) was investigated for O-arylation and N-arylation reactions. This phosphine-free complex was found as highly efficient heterogeneous catalyst in green media and mild reaction conditions. In addition, it gave excellent recyclability without significant deactivation after ten cycles.

HEAT SHOCK PROTEIN 90 INHIBITORS

Substituted aromatic compounds of formula (I) shown below: (formula I) The definition of each variable in formula (I) appears in the Specification. Also disclosed is a pharmaceutical composition containing one of the substituted aromatic compounds. Further disclosed is a method of using one of these compounds for treating a medical condition associated with HSP90.

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs)

Stem cell factor receptor (c-KIT) and platelet derived growth factor receptor alpha (PDGFRα) kinases play an important role in gastrointestinal stromal tumors (GISTs). Here, we have discovered an c-KIT/PDGFRα dual inhibitor, compound 31, with single-digit nanomolar potency against c-KIT and PDGFRα. Compared to Imatinib (1), 31 showed better antiproliferative efficacy against various TEL-c-KIT/PDGFRα-BaF3 isogenic cells, including three 1-resistant BaF3 cell lines, as well as against GIST-T1 and GIST-882 cell lines. Furthermore, compound 31 showed a good KinomeScan selectivity (468 kinases) (S score (1) = 0.01 at 1 μM concentration), good metabolic stability in liver microsomes, and no hERG inhibitory activity. It was worth noting that 31 inhibited GIST-T1 tumor growth (TGI = 81.5%) and even the BaF3-TEL-cKIT-T670I tumor progression (TGI = 41.9%, 1-resistant GISTs) at a dosage of 100 mg/kg/day without exhibiting apparent toxicity.