5333-01-7

Basic information

• Product Name: 1-BIPHENYL-4-YL-PROPAN-2-ONE
• Synonyms: 1-(4-phenylphenyl)propan-2-one;1-(4-phenylphenyl)acetone
• CAS NO: 5333-01-7
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 0
• Mol File: 5333-01-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 340.2°Cat760mmHg
• Flash Point: 164.4°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 8.74E-05mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 1-BIPHENYL-4-YL-PROPAN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BIPHENYL-4-YL-PROPAN-2-ONE(5333-01-7)
• EPA Substance Registry System: 1-BIPHENYL-4-YL-PROPAN-2-ONE(5333-01-7)

Safety Data

• Hazardous Substances Data: 5333-01-7(Hazardous Substances Data)

Usage

Chemical Structure

A benzoyl group attached to a biphenyl moiety

Usage

a. Organic synthesis reactions
b. Pharmaceutical and medicinal applications

Biological Activities

a. Anti-inflammatory
b. Anti-tumor
c. Potential benefits for treating neurodegenerative diseases

Application in Synthesis

Used as a building block in the synthesis of complex organic molecules

Importance

Valuable and versatile compound in the field of organic chemistry and drug development

InChI:InChI=1/C15H14O/c1-12(16)11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10H,11H2,1H3

Upstream product

• 10289-45-9 4-propyl-1,1'-biphenyl 
• 116-11-0 2-Methoxypropene 
• 1591-31-7 4-iodo-biphenyl 
• 110-82-7 cyclohexane 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 82804-30-6 2-biphenyl-4-yl-1-methyl-ethylamine; hydrochloride 
• 75251-26-2 α-Methyl-α-(phenylamino)-4-biphenylpropannitril 
• 75250-80-5 (Z)-N-<2-(4-Biphenylyl)-1-methylethyliden>benzolamin 
• 75250-81-6 (E)-N-<2-(4-Biphenylyl)-1-methylethyliden>benzolamin 
• 1333377-88-0 3-(biphenyl-4-yl)-1,2-diphenylpentane-1,4-dione 
• 1416355-14-0 C₁₉H₁₆N₂O₅ 
• 1416355-15-1 C₁₉H₁₆N₂O₅ 

Relevant articles and documents

Three-Component Alkene Difunctionalization by Direct and Selective Activation of Aliphatic C?H Bonds

Catalytic alkene difunctionalization is a powerful strategy for the rapid assembly of complex molecules and has wide range of applications in synthetic chemistry. Despite significant progress, a compelling challenge that still needs to be solved is the installation of highly functionalized C(sp3)-hybridized centers without requiring pre-activated substrates. We herein report that inexpensive and easy-to-synthesize decatungstate photo-HAT, in combination with nickel catalysis, provides a versatile platform for three-component alkene difunctionalization through direct and selective activation of aliphatic C?H bonds. Compared with previous studies, the significant advantages of this strategy are that the most abundant hydrocarbons are used as feedstocks, and various highly functionalized tertiary, secondary, and primary C(sp3)-hybrid centers can be easily installed. The practicability of this strategy is demonstrated in the selective late-stage functionalization of natural products and the concise synthesis of pharmaceutically relevant molecules including Piragliatin.

Homobenzylic Oxygenation Enabled by Dual Organic Photoredox and Cobalt Catalysis

Activation of aliphatic C(sp3)-H bonds in the presence of more activated benzylic C(sp3)-H bonds is often a nontrivial, if not impossible task. Herein we show that leveraging the reactivity of benzylic C(sp3)-H bonds to achieve reactivity at the homobenzylic position can be accomplished using dual organic photoredox/cobalt catalysis. Through a two-part catalytic system, alkyl arenes undergo dehydrogenation followed by an anti-Markovnikov Wacker-type oxidation to grant benzyl ketone products. This formal homobenzylic oxidation is accomplished with high atom economy without the use of directing groups, achieving valuable reactivity that traditionally would require multiple chemical transformations.