5333-65-3

Basic information

• Product Name: 1-(biphenyl-4-yloxy)propan-2-ol
• Synonyms: 2-Propanol, 1- ([1,1'-biphenyl]-4-yloxy)-; 2-Propanol, 1-(4-biphenylyloxy)-
• CAS NO: 5333-65-3
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.2863
• Mol File: 5333-65-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 384.6°C at 760 mmHg
• Flash Point: 174.1°C
• Density: 1.089g/cm³
• Vapor Pressure: 1.33E-06mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 1-(biphenyl-4-yloxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(biphenyl-4-yloxy)propan-2-ol(5333-65-3)
• EPA Substance Registry System: 1-(biphenyl-4-yloxy)propan-2-ol(5333-65-3)

Safety Data

• Hazardous Substances Data: 5333-65-3(Hazardous Substances Data)

Usage

Physical State

It is a white solid.

Molecular Weight

The molecular weight of 1-(biphenyl-4-yloxy)propan-2-ol is 210.27 g/mol.

Industrial Applications

The compound is used in various industrial applications, including as a building block in organic synthesis and as a reagent in chemical reactions.

Pharmaceutical and Agrochemical Production

It is also used in the production of pharmaceuticals and agrochemicals.

Hazard Classification

1-(biphenyl-4-yloxy)propan-2-ol is classified as a non-hazardous chemical.

Safety Precautions

Proper handling and storage protocols should be followed to ensure safety when working with this compound.

Upstream product

• 92-69-3 4-Phenylphenol 
• 18859-38-6 1-(p-phenylphenoxy)propan-2-one 

Relevant articles and documents

Selective Cross-Dehydrogenative C(sp3)-H Arylation with Arenes

Selective C(sp3)-C(sp2) bond construction is of central interest in chemical synthesis. Despite the success of classic cross-coupling reactions, the cross-dehydrogenative coupling between inert C(sp3)-H and C(sp2)-H bonds represents an attractive alternative toward new C(sp3)-C(sp2) bonds. Herein, we establish a selective inter-and intramolecular C(sp3)-H arylation of alcohols with nondirected arenes that thereby provides a general pathway to access a wide range of β-arylated alcohols, including tetrahydronaphthalen-2-ols and benzopyran-3-ols, with high to excellent chemo-and regioselectivity.

Formation of ketones from alkyl nitrites in the solid state

Alkyl nitrites selectively afforded the corresponding ketones upon photoirradiation in the solid state. It was suggested by the X-ray crystallographic analysis that the cavity in crystal and the initial conformation of the nitroso group had an influence on the yield of the ketones.