5334-40-7 Usage
Description
4-Nitropyrazole-3-carboxylic acid is a pyrazole derivative characterized by its white to off-white crystalline powder form. It is known for its catalytic activity when used with bimetallic colloids, such as silver nanoparticles partially coated with Pd clusters. 4-Nitropyrazole-3-carboxylic acid has been investigated using Surface-enhanced Raman scattering (SERS) spectroscopy, and its effects on blood flow and palladium hydrogenation have been studied.
Uses
Used in Pharmaceutical Synthesis:
4-Nitropyrazole-3-carboxylic acid is used as a building block for the synthesis of biologically active compounds. It serves as an intermediate in the synthesis of pyrazole-benzimidazole derivatives, which are potent Aurora A/B kinase inhibitors. These inhibitors play a crucial role in various therapeutic applications, particularly in the treatment of cancer.
Used in Drug Discovery:
4-Nitropyrazole-3-carboxylic acid may also be used as a starting reagent for the synthesis of a library of pyrazole derivatives. These derivatives have the potential to act as A3 adenosine receptor (A3AR) antagonists, which can be beneficial in the development of drugs targeting various diseases and conditions.
Used in Chemical Research:
4-Nitropyrazole-3-carboxylic acid is utilized in chemical research to study its catalytic properties when combined with bimetallic colloids. 4-Nitropyrazole-3-carboxylic acid's interaction with silver nanoparticles and Pd clusters has been investigated using SERS spectroscopy, providing valuable insights into its potential applications in catalysis and other chemical processes.
Used in the Study of Blood Flow:
The effects of 4-Nitropyrazole-3-carboxylic acid on blood flow have been studied, which could have implications for its use in the development of drugs targeting cardiovascular diseases or conditions affecting blood circulation.
Used in Palladium Hydrogenation Studies:
4-Nitropyrazole-3-carboxylic acid's palladium hydrogenation has been researched, which could contribute to the understanding of its chemical properties and potential applications in various industrial or pharmaceutical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 5334-40-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,3 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5334-40:
(6*5)+(5*3)+(4*3)+(3*4)+(2*4)+(1*0)=77
77 % 10 = 7
So 5334-40-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H3N3O4/c8-4(9)3-2(7(10)11)1-5-6-3/h1H,(H,5,6)(H,8,9)
5334-40-7Relevant articles and documents
A green and facile approach for synthesis of nitro heteroaromatics in water
Zhao, Xiu X.,Zhang, Ji C.,Li, Sheng H.,Yang, Qing P.,Li, Yu C.,Pang, Si P.
, p. 886 - 890 (2014/08/05)
A convenient and green method for the oxidation of nitrogen-rich heterocyclic amines to nitro-substituted heteroaromatics using potassium peroxymonosulfate (2KHSO5·KHSO4·K 2SO4, Oxone) in water was developed. This method has several advantages over previous methods: operational simplicity, safety, inexpensive reagents, the use of H2O as the sole solvent, and mild conditions. The utility of the present oxidative system was demonstrated by the synthesis of the important energetic compounds 3,4,5-trinitro-1H-pyrazole (TNP) and 5-amino-3-nitro-1H-1,2,4-triazole (ANTA).