5336-08-3 Usage
Description
D(+)-Ribonic acid gamma-lactone, also known as D-ribono-1,4-lactone, is a five-membered form of ribonolactone with D-configuration. It is a white crystalline solid that serves as an important chiral synthon in organic synthesis and is also a compound useful in organic synthesis.
Uses
1. Used in Pharmaceutical Industry:
D(+)-Ribonic acid gamma-lactone is used as an inhibitor of β-galactosidase of E. coli for its potential applications in the development of drugs targeting bacterial infections.
2. Used in Organic Synthesis:
D(+)-Ribonic acid gamma-lactone is used as an important chiral synthon for its role in the synthesis of various organic compounds, contributing to the development of new pharmaceuticals and chemicals.
3. Used in Research and Development:
D(+)-Ribonic acid gamma-lactone is used as a compound useful in organic synthesis, playing a significant role in the research and development of new chemical entities and materials.
Purification Methods
Purify D-(+)-ribonic acid--lactone by recrystallisation from EtOAc. The tribenzoate has m 54-56o (from AcOH), [] D 25 +27o (c 2.37, Me2NCHO), and the 3,5-O-benzylidene derivative has m 230-231.5o (needles from Me2CO-pet ether) and [] D 25 -177o (CHCl3). [Chen & Joulié J Org Chem 49 2168 1984, Zinner & Voigt J Carbohydr Research 7 38 1968.]
Check Digit Verification of cas no
The CAS Registry Mumber 5336-08-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,3 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5336-08:
(6*5)+(5*3)+(4*3)+(3*6)+(2*0)+(1*8)=83
83 % 10 = 3
So 5336-08-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H8O5/c6-1-2-3(7)4(8)5(9)10-2/h2-4,6-8H,1H2/t2?,3-,4-/m1/s1
5336-08-3Relevant articles and documents
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Novikov et al.
, (1976)
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Novel synthesis method for synthesizing remdesivir
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Paragraph 0073-0076, (2021/08/14)
The invention discloses a novel synthesis method for synthesizing remdesivir. According to the synthesis method disclosed by the invention, D-ribose is taken as a raw material and is subjected to a series of reactions such as oxidation, cyclohexanone protection, silanization protection, substitution, substitution, deprotection, coupling, deprotection and the like to synthesize the remdesivir. The post-treatment operation is optimized, and the method has the advantages of being short in reaction time, high in yield, low in cost, suitable for industrial production and the like. The structure of the remdesivir provided by the invention is shown in the specification.
Antioxidant composition comprising marliolide derivatives
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Paragraph 0039-0045, (2019/11/23)
The present invention relates to a marliolide derivative and an antioxidant composition containing the same as an active component, wherein the marliolide derivative increases the expression of a transcription factor Nrf2 that regulates the expression of an antioxidant-related protein without cytotoxicity, thereby increasing the expression of HO-1 and NQO1, which are antioxidant-related proteins. In addition, since the marliolide derivative is confirmed to inhibit the oxidation of DNA and lipids induced by TPA that induces oxidative stress, a composition containing the marliolide derivative can be provided as the antioxidant composition.(AA) Compound 1 (10 andmu;M)COPYRIGHT KIPO 2019
