5336-17-4

Basic information

• Product Name: N-Ethyliminodiacetic acid
• Synonyms: N-Ethyliminodiacetic acid;2,2'-(Ethylimino)diacetic acid;Ethyliminobisacetic acid;2,2'-(ethylazanediyl)diacetic acid;Glycine, N-(carboxyMethyl)-N-ethyl-
• CAS NO: 5336-17-4
• Molecular Formula: C6H11NO4
• Molecular Weight: 161.1558
• Mol File: 5336-17-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 338.2 °C at 760 mmHg
• Flash Point: 158.3 °C
• Appearance: /
• Density: 1.298 g/cm³
• PKA: 1.85±0.10(Predicted)
• CAS DataBase Reference: N-Ethyliminodiacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyliminodiacetic acid(5336-17-4)
• EPA Substance Registry System: N-Ethyliminodiacetic acid(5336-17-4)

Safety Data

• Hazardous Substances Data: 5336-17-4(Hazardous Substances Data)

Usage

General Description

N-Ethyliminodiacetic acid (also known as "Hydroxyiminodiacetic acid ethyl ester" or "Glycine, N,N'-1,2-ethanediylbis-, bis(ethyl ester)") is an organic chemical compound, more specifically an amino acid derivative. It is often used in the field of chemistry in various applications due to its reactive nature. Besides being hazardous when ingested or coming into contact with eyes or skin, it also poses threats to aquatic life due to long-term environmental damage. Hence, appropriate storage and handling precautions should be adhered to while dealing with this compound.

Upstream product

• 50-00-0 formaldehyd 
• 143-33-9 sodium cyanide 
• 75-04-7 ethylamine 
• 79-11-8 chloroacetic acid 
• 75-03-6 ethyl iodide 
• 91017-42-4 ethylimino-di-acetic acid diethyl ester 
• 75-07-0 acetaldehyde 
• 142-73-4 iminodiacetic acid 

Relevant articles and documents

Synthesis and structure revision of dimeric tadalafil analogue adulterants in dietary supplements

A number of phosphodiesterase 5 (PDE5) inhibitors approved by authorities have been used successfully in the treatment of erectile dysfunction. These medicines must be prescribed carefully due to their adverse effects, but they and their analogues are being illegally added to dietary supplements. These illegal dietary supplements pose a significant risk to public health. Several dimeric tadalafil analogues have been synthesized for use as reference standards in the inspection of functional foods that are mainly advertised as sexual enhancement products. During the course of this synthesis, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU) was proven to be the reagent of choice for amide coupling to produce these dimeric tadalafil analogues. Moreover, the trans-isomer structures tentatively assigned for the isolated dimeric tadalafil analogues (bisprehomotadalafil and bisprecyclopentyltadalafil) found in dietary supplements are now revised to cis-isomer structures.