5336-90-3 Usage
Description
9-ACRIDINECARBOXYLIC ACID is a bright yellow to yellow-green crystalline powder that is widely utilized in various applications due to its unique chemical properties. It is a compound derived from the acridine family, which is known for its diverse biological activities and potential pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
9-ACRIDINECARBOXYLIC ACID is used as a key intermediate in the synthesis of short DNA-binding peptides. These peptides have significant potential in the development of novel therapeutic agents targeting genetic disorders and other diseases at the molecular level.
Used in Enzyme Inhibition:
9-ACRIDINECARBOXYLIC ACID is employed as an inhibitor for α-amylase and α-glucosidase enzymes. This application is particularly relevant in the management of diabetes, as it helps regulate the breakdown and absorption of carbohydrates, thereby controlling blood sugar levels.
Used in Kinetic Studies:
9-ACRIDINECARBOXYLIC ACID is used as a tool in kinetic studies to understand the mechanisms of enzyme-catalyzed reactions. By studying the interactions between 9-ACRIDINECARBOXYLIC ACID and various enzymes, researchers can gain insights into the factors that influence reaction rates and develop more effective drugs.
Used in Structure-Activity Relationship (SAR) Studies:
9-ACRIDINECARBOXYLIC ACID is used in SAR studies to evaluate the relationship between the chemical structure of a compound and its biological activity. This information is crucial for the design and optimization of new drugs with improved efficacy and safety profiles.
Used in Cytotoxicity Assessment:
9-ACRIDINECARBOXYLIC ACID is utilized in cytotoxicity assays to assess the potential harmful effects of various substances on cells. This information is essential for the development of safe and effective drugs, as well as for understanding the mechanisms of cell damage and death.
Used in Antitumor Activity Research:
9-ACRIDINECARBOXYLIC ACID is used in the investigation of antitumor activities, particularly in the development of ((benzyltriazolyl)methyl)acridine carboxamides. These compounds have shown promise in inhibiting tumor growth and progression, making them potential candidates for cancer therapy.
Used in Molecular Docking Studies:
9-ACRIDINECARBOXYLIC ACID is employed in molecular docking studies to predict the binding affinity and orientation of ligands to their target proteins. This information is valuable for the design of new drugs with high specificity and potency, as well as for understanding the molecular basis of drug action and resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 5336-90-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,3 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5336-90:
(6*5)+(5*3)+(4*3)+(3*6)+(2*9)+(1*0)=93
93 % 10 = 3
So 5336-90-3 is a valid CAS Registry Number.
5336-90-3Relevant articles and documents
Online Investigation of Aqueous-Phase Electrochemical Reactions by Desorption Electrospray Ionization Mass Spectrometry
Lu, Mei,Liu, Yong,Helmy, Roy,Martin, Gary E.,Dewald, Howard D.,Chen, Hao
, p. 1676 - 1685 (2015/09/22)
Electrochemistry (EC) combined with mass spectrometry (MS) is a powerful tool for elucidation of electrochemical reaction mechanisms. However, direct online analysis of electrochemical reaction in aqueous phase was rarely explored. This paper presents the online investigation of several electrochemical reactions with biological relevance in the aqueous phase, such as nitrosothiol reduction, carbohydrate oxidation, and carbamazepine oxidation using desorption electrospray ionization mass spectrometry (DESI-MS). It was found that electroreduction of nitrosothiols [e.g.; nitrosylated insulin B (13-23)] leads to free thiols by loss of NO, as confirmed by online MS analysis for the first time. The characteristic mass shift of 29 Da and the reduced intensity provide a quick way to identify nitrosylated species. Equally importantly, upon collision-induced dissociation (CID), the reduced peptide ion produces more fragment ions than its nitrosylated precursor ion (presumably the backbone fragmentation cannot compete with the facile NO loss for the precursor ion), thus facilitating peptide sequencing. In the case of saccharide oxidation, it was found that glucose undergoes electro-oxidation to produce gluconic acid at alkaline pH, but not at neutral and acidic pHs. Such a pH-dependent electrochemical behavior was also observed for disaccharides such as maltose and cellobiose. Upon electrochemical oxidation, carbamazepine was found to undergo ring contraction and amide bond cleavage, which parallels the oxidative metabolism observed for this drug in leucocytes. The mechanistic information of these redox reactions revealed by EC/DESI-MS would be of value in nitroso-proteome research and carbohydrate/drug metabolic studies.
