53361-40-3

Basic information

• Product Name: Diethyl 2-(4-(benzyloxy)benzylidene)malonate
• Synonyms: DIETHYL2-(4-(BENZYLOXY)BENZYLIDENE)MALONATE
• CAS NO: 53361-40-3
• Molecular Formula: C₂₁H₂₂O₅
• Molecular Weight: 354.4
• Mol File: 53361-40-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 466.1 °C at 760 mmHg
• Flash Point: 202.3 °C
• Appearance: /
• Density: 1.164 g/cm³
• Vapor Pressure: 7.27E-09mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: Diethyl 2-(4-(benzyloxy)benzylidene)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl 2-(4-(benzyloxy)benzylidene)malonate(53361-40-3)
• EPA Substance Registry System: Diethyl 2-(4-(benzyloxy)benzylidene)malonate(53361-40-3)

Safety Data

• Hazardous Substances Data: 53361-40-3(Hazardous Substances Data)

Usage

General Description

Diethyl 2-(4-(benzyloxy)benzylidene)malonate is a chemical compound with the molecular formula C21H22O5. It is an organic compound that is derived from malonic acid and contains two ester groups. The compound has a benzylidene group and a benzyloxy group, giving it aromatic and ether-like qualities. It is commonly used as a building block in organic synthesis and has applications in the production of pharmaceuticals and agrochemicals. The compound may also have potential uses in materials science and other industrial applications due to its unique chemical structure.

InChI:InChI=1/C21H22O5/c1-3-24-20(22)19(21(23)25-4-2)14-16-10-12-18(13-11-16)26-15-17-8-6-5-7-9-17/h5-14H,3-4,15H2,1-2H3

Upstream product

• 110-89-4 piperidine 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 105-53-3 diethyl malonate 
• 17315-86-5 2-(4-hydroxybenzylidene)malonic acid diethyl ester 
• 100-44-7 benzyl chloride 

Downstream Products

• 1427010-07-8 C₂₃H₁₈N₂O₃ 
• 1092074-21-9 C₂₉H₂₂N₂O₃ 

Relevant articles and documents

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

We have explored here the scope of the age-old diethyl malonate-based accesses to α-amino esters involving Knoevenagel condensations of diethyl malonate on aldehydes, reductions of the resulting alkylidenemalonates, the preparation of the corresponding α-hydroxyimino esters and their final reduction. This synthetic pathway turned out to be general although some unexpected limitations were encountered. The synthetic modifications of some of the intermediates - using Suzuki-Miyaura coupling or cycloadditions - before undertaking the oximation step - provided accesses to further α-amino esters. Moreover, other pathways to α-hydroxyimino esters were explored including an attempt to improve the cycloadditions between ethyl β-bromo-α-hydroxyiminocarboxylate and various alkylfuranes.

Piperidine derivatives having renin inhibiting activity

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.