53443-78-0

Basic information

• Product Name: 2-methyl-N-prop-2-yn-1-yl-benzenamine
• Synonyms: 2-methyl-N-prop-2-yn-1-yl-benzenamine
• CAS NO: 53443-78-0
• Molecular Weight: 145.204
• Mol File: 53443-78-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-methyl-N-prop-2-yn-1-yl-benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N-prop-2-yn-1-yl-benzenamine(53443-78-0)
• EPA Substance Registry System: 2-methyl-N-prop-2-yn-1-yl-benzenamine(53443-78-0)

Safety Data

• Hazardous Substances Data: 53443-78-0(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 74965-31-4 N-(tert-butoxycarbonyl)-o-toluidine 
• 106-96-7 propargyl bromide 

Downstream Products

• 1616979-06-6 C₂₅H₃₀N₄O₄ 
• 1092371-28-2 9-[4-(o-tolylamino-methyl)-[1,2,3]triazol-1-yl]-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1092371-29-3 5-(4-hydroxy-3,5-dimethoxy-phenyl)-9-[4-(o-tolylamino-methyl)-[1,2,3]triazol-1-yl]-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 15316-91-3 N-allyl-o-toluidine 

Relevant articles and documents

One-pot preparation of pyrrole derivatives via the copper-catalyzed [4+1] annulation of propargylic amines with ethyl glyoxylate and phenylglyoxal in the presence of piperidine

We describe how copper(II) chloride efficiently catalyzes the [4+1] annulation of propargylamines with either ethyl glyoxylate or phenylglyoxal functioning as a C1 unit, in the presence of piperidine, which leads to a straightforward and one-pot preparati

Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids

MRSA causes 60-70% of Staphylococcus aureus infection in hospitals and it has developed resistance against the currently available drugs. Interestingly, a series of 35 metronidazole-triazole hybrids on screening against MRSA were found to be active. Compound 22 was found to be effective at 4 μg/mL concentration against nine strains of MRSA. The inhibitory activity was further enhanced upto 1 μg/mL when this compound was used in combination with oxacillin in 1:1 ratio. All the compounds were found to be non-toxic in THP-1 cell line upto a concentration of 50 μM. The time-kill kinetics studies suggested bacteriostatic nature of the compounds. In silico studies show that these compounds interact with Thr600, Ser598, Asn464, His583 and Tyr446 in the active site of PBP2a crystal structure from MRSA.

Copper(II)-Catalyzed [4+1] annulation of propargylamines with N,O-acetals: Entry to the synthesis of polysubstituted pyrrole derivatives

Described herein is the CuCl2-catalyzed [4+1] annulation of a variety of propargylamines with N,O-acetals that function as a C1 unit, leading to the production of polysubstituted pyrrole derivatives. Three important features of the N,O-acetal during the [4+1] annulation series via 5-endo-dig cyclization are described: an enolizable substituent adjacent to the central sp3-carbon is required, the central sp3-carbon displays the functions of both an electrophile and a nucleophile, and liberation of the secondary amine smoothly leads to the aromatization. A CuCl2-catalyzed [4+1] annulation of propargylamines with N,O-acetals having an ester, a ketone, and an amide moiety, leading to the facile preparation of polysubstituted pyrrole derivatives is presented. This annulation series was achieved through 5-endo-dig cyclization and subsequent aromatization in one pot.