5350-97-0Relevant articles and documents
Microwave solvent-free synthesis of nitrocyclohexanols
Correc, Olivier,Guillou, Karine,Hamelin, Jack,Paquin, Ludovic,Texier-Boullet, Fran?oise,Toupet, Lo?c
, p. 391 - 395 (2004)
New nitrocyclohexanols 3a-f are synthesized by a clean and original method from nitromethane 1 and unsaturated ketones 2a-f in the presence of solid potassium fluoride-alumina under solvent-free conditions coupled with microwave irradiation. The reaction involves a double and diastereoselective Michael addition followed by ring closure. Another diastereomer 3′, which differs by the configuration of C-4, is obtained in the presence of piperidine and EtOH at room temperature.
An efficient and improved synthesis of 1,5-diketones: versatile conjugate addition of nucleophiles to α,β-unsaturated enones and alkynones
Shankar, Ravi,Jha, Ashok K.,Singh, Uma Sharan,Hajela
, p. 3077 - 3079 (2007/10/03)
Several 1,5-diketones have been prepared in good to excellent yields by versatile conjugate addition of nucleophiles such as cyclic or acyclic ketones, amines and thiols to α,β-unsaturated enones and alkynones, in the presence of catalytic amounts of 10%
Water promoted Michael addition of secondary amines: To α,β- unsaturated carbonyl compounds under microwave irradiation
Matloubi Moghaddam, Firouz,Mohammadi, Mohsen,Hosseinnia, Azarmidocht
, p. 643 - 650 (2007/10/03)
A rapid Michael addition of secondary amines to α,β-unsaturated carbonyl compounds has been achieved in good to excellent yields in the presence of water under microwave irradiation. In the absence of water and under conventional method the reaction does not proceed or take place in very low yield after a long reaction time.
