53531-01-4 Usage
Description
4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester, also known as Trimetazidine N-Carboxylic Acid Ethyl Ester, is an impurity found in Trimetazidine (T795610). It is a chemical compound derived from the parent drug Trimetazidine, which is used for various therapeutic purposes. 4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester features a unique structure with a trimethoxyphenylmethyl group attached to a piperazinecarboxylic acid, which is further esterified with an ethyl group.
Uses
Used in Pharmaceutical Industry:
4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester is used as an impurity in the synthesis and production of Trimetazidine for [application reason]. Trimetazidine is a medication used to improve energy metabolism in cardiac and vascular tissues, making it a valuable compound in the treatment of various cardiovascular conditions.
As an impurity, the presence of 4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester in Trimetazidine may affect the drug's efficacy, safety, and overall quality. Therefore, it is essential to monitor and control the levels of this impurity during the manufacturing process to ensure the drug meets the required standards for therapeutic use.
Additionally, understanding the properties and potential effects of this impurity can help researchers and pharmaceutical companies develop strategies to minimize its presence or mitigate its impact on the drug's performance. This may involve refining the synthesis process, implementing advanced purification techniques, or exploring alternative formulations to reduce the occurrence of this impurity in the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 53531-01-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,5,3 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 53531-01:
(7*5)+(6*3)+(5*5)+(4*3)+(3*1)+(2*0)+(1*1)=94
94 % 10 = 4
So 53531-01-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H26N2O5/c1-5-24-17(20)19-10-8-18(9-11-19)12-13-6-7-14(21-2)16(23-4)15(13)22-3/h6-7H,5,8-12H2,1-4H3
53531-01-4Relevant articles and documents
Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships
Ferté, Jacques,Kühnel, Jean-Marc,Chapuis, Geneviève,Rolland, Yves,Lewin, Guy,Schwaller, Marc A.
, p. 478 - 489 (2007/10/03)
A series of 28 flavonoid derivatives containing a N-benzylpiperazine chain have been synthesized and tested for their ability to modulate multidrug resistance (MDR) in vitro. At 5 μM, most compounds potentiated doxorubicin cytotoxicity on resistant K562/DOX cells. They were also able to increase the intracellular accumulation of JC-1, a fluorescent molecule recently described as a probe of P-glycoprotein-mediated MDR. This suggests that these compounds act, at least in part, by inhibiting P-glycoprotein activity. As in other studies, lipophilicity was shown to influence MDR- modulating activity but was not the only determinant. Diverse di- and trimethoxy substitutions on N-benzyl were examined and found to affect the activity differently. The most active compounds had a 2,3,4- trimethoxybenzylpiperazine chain attached to either a flavone or a flavanone moiety (13, 19, 33, and 37) and were found to be more potent than verapamil.
