53578-11-3

Basic information

• Product Name: 4-Nitro-1-(pyrrolidinocarbonyl)benzene
• Synonyms: 4-Nitro-1-(pyrrolidinocarbonyl)benzene
• CAS NO: 53578-11-3
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.22458
• Mol File: 53578-11-3.mol
• Article Data: 50

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Nitro-1-(pyrrolidinocarbonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-1-(pyrrolidinocarbonyl)benzene(53578-11-3)
• EPA Substance Registry System: 4-Nitro-1-(pyrrolidinocarbonyl)benzene(53578-11-3)

Safety Data

• Hazardous Substances Data: 53578-11-3(Hazardous Substances Data)

Usage

Description

4-Nitro-1-(pyrrolidinocarbonyl)benzene, also known as NPCB, is a nitroaromatic chemical compound with a molecular formula C13H12N2O3. It is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. NPCB is often used as a building block in organic synthesis and serves as a starting material for the synthesis of various drugs and pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
4-Nitro-1-(pyrrolidinocarbonyl)benzene is used as a starting material for the synthesis of various drugs and pharmaceutical compounds. Its unique chemical structure allows for the development of new and innovative medications.
Used in Research Laboratories:
NPCB is used as a reagent for the modification of proteins and peptides. Its ability to interact with these biomolecules makes it a valuable tool in scientific research for studying protein structure, function, and interactions.
However, it is important to note that 4-Nitro-1-(pyrrolidinocarbonyl)benzene is toxic and potentially harmful if ingested or inhaled. Therefore, it should be handled with care and proper safety precautions should be taken during its use.

Upstream product

• 123-75-1 pyrrolidine 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 4231-71-4 1H-1,2,3-benzotriazol-1-yl-4-nitrophenylmethanone 
• 122-04-3 4-nitro-benzoyl chloride 
• 555-16-8 4-nitrobenzaldehdye 
• 62-23-7 4-nitro-benzoic acid 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 30364-58-0 p-nitrobenzoic acid N-hydroxysuccinimide ester 
• 13939-06-5 molybdenum hexacarbonyl 
• 168090-27-5 N-(4-nitrobenzoyl)succinimide 
• 25393-54-8 N-(4-nitrobenzoyl)oxazolidinone 
• 61273-18-5 4-nitro-benzoic acid-(2,2,2-trichloro-ethyl ester) 
• 25407-30-1 4-nitrophenacylpyridinium bromide 

Downstream Products

• 119741-53-6 1-(4-nitrobenzoyl)pyrrolidin-2-one 
• 56302-41-1 4-carboxamidopyrrolidinophenyl-aniline 
• 1019018-76-8 (4-amino-3-bromo-phenyl)-pyrrolidin-1-yl-methanone 
• 877603-33-3 4-(pyrrolidinylcarbonyl)phenylamine hydrochloride 
• 50903-06-5 (4-nitrophenyl)(pyrrolidin-1yl)methanethione 
• 694-00-8 pyrrolidine-1-d₁ 
• 2906-29-8 4-nitrobenzoate 
• 133851-67-9 1-(4-nitro-benzyl)-pyrrolidine 

Relevant articles and documents

Visible-Light-Mediated Oxidative Amidation of Aldehydes by Using Magnetic CdS Quantum Dots as a Photocatalyst

A magnetic CdS quantum dot (Fe3O4/polydopamine (PDA)/CdS) was synthesized through a facile and convenient method from inexpensive starting materials. Characterization of the prepared catalyst was performed by means of FTIR spectrosco

Amide Bond Formation via Aerobic Photooxidative Coupling of Aldehydes with Amines Catalyzed by a Riboflavin Derivative

We report an effective, operationally simple, and environmentally friendly system for the synthesis of tertiary amides by the oxidative coupling of aromatic or aliphatic aldehydes with amines mediated by riboflavin tetraacetate (RFTA), an inexpensive organic photocatalyst, and visible light using oxygen as the sole oxidant. The method is based on the oxidative power of an excited flavin catalyst and the relatively low oxidation potential of the hemiaminal formed by amine to aldehyde addition.

A practical catalytic reductive amination of carboxylic acids

We report reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)2-catalyzed amide reduction. The reaction is applicable to a wide range of amines and carboxylic acids and has been demonstrated on a large scale (305 mmol of amine). The rate differential between the reduction of tertiary and secondary amide intermediates is exemplified in a convergent synthesis of the antiretroviral medicine maraviroc. Mechanistic studies demonstrate that a residual 0.5 equivalents of carboxylic acid from the amidation step is responsible for the generation of silane reductants with augmented reactivity, which allow secondary amides, previously unreactive in zinc/phenylsilane systems, to be reduced.