5373-87-5

Basic information

• Product Name: N'-Hydroxy-4-methoxybenzenecarboximidamide
• Synonyms: 4-methoxybenzamidoxime;anisamidoxime;n-hydroxy-4-methoxy-benzenecarboximidamid;p-anisamidoxime;p-methoxybenzamideoxime;N-HYDROXY-4-METHOXY-BENZAMIDINE;N'-HYDROXY-4-METHOXYBENZENECARBOXIMIDAMIDE;N'-Hydroxy-4-methoxybenzenecarboximideamide
• CAS NO: 5373-87-5
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Product Categories: pharmacetical
• Mol File: 5373-87-5.mol
• Article Data: 110

Chemical Properties

• Melting Point: 122-128°C
• Boiling Point: 344.8 °C at 760 mmHg
• Flash Point: 162.3 °C
• Appearance: /
• Density: 1.21 g/cm³
• CAS DataBase Reference: N'-Hydroxy-4-methoxybenzenecarboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-Hydroxy-4-methoxybenzenecarboximidamide(5373-87-5)
• EPA Substance Registry System: N'-Hydroxy-4-methoxybenzenecarboximidamide(5373-87-5)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• RTECS: BZ3425000
• HazardClass: IRRITANT
• Hazardous Substances Data: 5373-87-5(Hazardous Substances Data)

Usage

General Description

N'-Hydroxy-4-methoxybenzenecarboximidamide, also known as 4-Methoxybenzohydroxamic acid, is a chemical compound with the molecular formula C8H9NO3. It is a derivative of hydroxamic acid, which is known for its ability to chelate metal ions. N'-Hydroxy-4-methoxybenzenecarboximidamide has been studied for its potential applications in various fields, including medicine, biochemistry, and environmental science. It exhibits strong metal chelating properties, making it useful in metal ion removal and purification processes. Additionally, it has shown potential as an anticancer agent, as well as in the treatment of neurological disorders. Further research is ongoing to explore its potential uses and applications.

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 67-56-1 methanol 
• 64-17-5 ethanol 
• 7803-49-8 hydroxylamine 
• 3717-22-4 (Z)-para-methoxybenzaldehyde oxime 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 860584-94-7 (+/-)-4-(chloro-nitroso-methyl)-anisole 
• 3717-21-3 p-methoxyl benzaldoxime 
• 123-11-5 4-methoxy-benzaldehyde 
• 68451-74-1 C₁₅H₁₄N₂O₃ 
• 68451-88-7 C₁₅H₁₃ClN₂O₃ 
• 68451-81-0 C₁₆H₁₆N₂O₄ 
• 68451-94-5 (Z)-4-methoxy-N'-((4-nitrobenzoyl)oxy)benzimidamide 

Downstream Products

• 94192-18-4 3-<(3-p-Anisyl)-1,2,4-oxadiazol-5-yl>propionic acid 
• 220662-63-5 N-ethoxycarbonyloxy-4-methoxy-benzamidine 
• 59812-04-3 3-p-methoxyphenyl-4,5-dihydro-1,2,4-oxadiazol-5-one 
• 5311-71-7 methyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl ether 
• 75273-66-4 3-(4-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole 
• 68451-74-1 N-benzoyloxy-4-methoxy-benzamidine 
• 949-02-0 N-acetoxy-4-methoxy-benzamidine 
• 73217-70-6 5-dichloromethyl-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 58589-03-0 5-(2-aminophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 16013-13-1 3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 95373-36-7 N-(3-chloro-propionyloxy)-4-methoxy-benzamidine 
• 95844-44-3 N-(4-chloro-butyryloxy)-4-methoxy-benzamidine 
• 81467-51-8 C₁₂H₁₄N₂O₄ 
• 131012-98-1 3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-azabicyclo[2.2.2]octane 

Relevant articles and documents

1,2,4-Triazolium ions as flexible scaffolds for the construction of polyphilic ionic liquid crystals

A novel scaffold for the construction of self-organised ionic liquids and ionic liquid crystals bearing both perfluorocarbon and hydrocarbon moieties has been developed. The phase behaviour and physical properties of these materials can be tuned as a function of chain length and fluorine content and significant structural elaboration is possible, giving a highly flexible system.

Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity

Recent studies have shown that combining kinase inhibitors has additive and synergistic effects. BRAFV600E and p38α have been extensively studied as potential therapeutic targets for a variety of diseases. In keeping with our interest in developing multi-targeted anticancer agents, a series of novel triaryl-imidazole-based analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4a-h, Scaffold B) and their reaction intermediates aryl carboximidamides moiety (3a-h, Scaffold A) have been rationally designed, synthesized, and evaluated in vitro for their antiproliferative activity as dual p38α/BRAFV600E inhibitors. The results revealed that the presence of the carboximidamide moiety is required for activity, and the best activity correlates with the Ar = 1,2-benzodioxole (3e) ≥ 4-CH3O-C6H5-(3c) > 2-naphthyl (3h) > 4-Cl-C6H5 (3b). Ring closure of carboximidamide to 1,2,4-oxadiazole significantly reduces the activity. The results of docking study into p38α revealed higher binding affinities for compounds 3c, 3e, and 3h compared to the co-crystallized ligand, SB2. However, the docking study of compounds 3c and 3e into BRAFV600E revealed slightly lower affinities than vemurafenib.

2-(1,2,4-Oxadiazol-5-yl)anilines Based on Amidoximes and Isatoic Anhydrides: Synthesis and Structure Features

Abstract: An efficient one-pot method was developed for the synthesis of 2-(1,2,4-oxadiazol-5-yl)anilines via the reaction of amidoximes with isatoic anhydrides in a NaOH–DMSO medium at ambient temperature. The method allows to obtain structurally diverse