53750-66-6

Basic information

• Product Name: 4-Chloro-pyridine-2-carbonyl chloride
• Synonyms: 4-Chloro-pyridine-2-carbonyl chloride;4-CHLOROPHCOLINOYL CHLORIDE;4-chloro-picolinic acid chloride;4-Chloro-2-(chlorocarbonyl)pyridine, 4-Chloro-2-picolinoyl chloride;(4-chloropyridin-2-yl)(forMyl)chloranuide;4-chloropicolinoyl chloride;2-Pyridinecarbonyl chloride, 4-chloro-;4-Chloropyridine-2-carbonyl chlorid
• CAS NO: 53750-66-6
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176.00012
• Product Categories: Carbonyl Chlorides;Pyridines;Carbonyl Chlorides
• Mol File: 53750-66-6.mol
• Article Data: 95

Chemical Properties

• Boiling Point: 227.2ºC at 760 mmHg
• Flash Point: 91.2ºC
• Appearance: /
• Density: 1.454 g/cm³
• Vapor Pressure: 0.078mmHg at 25°C
• Refractive Index: 1.566
• PKA: -1.45±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-pyridine-2-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-pyridine-2-carbonyl chloride(53750-66-6)
• EPA Substance Registry System: 4-Chloro-pyridine-2-carbonyl chloride(53750-66-6)

Safety Data

• Hazardous Substances Data: 53750-66-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-pyridine-2-carbonyl chloride is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a chlorinated derivative of pyridine, which is a heterocyclic aromatic compound. The carbonyl chloride group makes this compound reactive and useful as a building block for creating various organic compounds. It is often used as an intermediate in the manufacturing of pharmaceuticals and agrochemicals. This chemical has a wide range of applications in the research and development of new drugs and agricultural products. However, it is important to handle 4-Chloro-pyridine-2-carbonyl chloride with care due to its reactivity and potential hazards.

InChI:InChI=1/C6H3Cl2NO/c7-4-1-2-9-5(3-4)6(8)10/h1-3H

Upstream product

• 5470-22-4 4-chloropicolinic acid 
• 35895-54-6 2-carboxy-4-chloropyridine-1-oxide 
• 98-98-6 2-Picolinic acid 
• 14933-78-9 2-carboxy-4-nitropyridine-1-oxide 
• 59-67-6 nicotinic acid 

Downstream Products

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 5470-22-4 4-chloropicolinic acid 
• 133928-61-7 N-phenyl-4-chloro-2-pyridinecarboxamide 
• 29681-43-4 methyl 4-methoxypicolinate 
• 71777-70-3 Ethyl 4-ethoxypicolinate 
• 260783-12-8 4-chloro-2-pyridinecarboxylic acid pyrrolidine amide 
• 99586-65-9 4-chloropicolinamide 
• 168428-76-0 4-chloro-2-pyridine carboxylic acid N,N-diisopropylamide 
• 640295-96-1 4-{3-[(4-chloro-pyridine-2-carbonyl)-amino]-naphthalen-2-yloxy}-phthalic acid dimethyl ester 
• 640296-30-6 4-{2-[(4-chloro-pyridine-2-carbonyl)-amino]-4-fluoro-phenoxy}-phthalic acid dimethyl ester 
• 220000-87-3 4-chloro-N-methylpicolinamide 
• 446019-94-9 4-methoxy-2-pyridine carboxylic acid N,N-diisopropylamide 
• 63071-10-3 (4-chloropyridin-2-yl)methanol 
• 133928-62-8 4-Chloro-3-methyl-pyridine-2-carboxylic acid phenylamide 

Relevant articles and documents

Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic molecules are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chemistry.

METHODS OF USING REBASTINIB IN THE TREATMENT OF DISORDERS

Described herein are methods of treating various disorders in patients in need thereof, comprising administering to the patient the compound of Formula (I) or a pharmaceutically acceptable salt thereof. Exemplary disorders that can be treated by the methods described herein include gynecologic carcinosarcomas, endometrial adenocarcinomas, mesotheliomas, ovarian cancers, pancreatic ductal adenocarcinomas, and lung cancers.

Picolinamide compound containing triazole or quinolinone structure and application of picolinamide compound

The invention provides a picolinamide compound containing a triazole or quinolinone structure and application of the picolinamide compound. According to a technical scheme in the invention, extensiveresearch is conducted on the picolinamide compound, and