53783-83-8 Usage
Description
Tromantadine is an antiviral medicine specifically designed to treat herpes simplex virus infections. It is effective in managing the symptoms and preventing the spread of the virus. Tromantadine is available in a topical gel formulation under the trade names Viru-Merz and Viru-Merz Serol, and its performance is comparable to that of acyclovir.
Uses
Used in Pharmaceutical Industry:
Tromantadine is used as an antiviral agent for the treatment of herpes simplex infections. It helps in reducing the severity and duration of the symptoms associated with the virus, providing relief to the patients.
Used in Topical Medication:
Tromantadine is used as an active ingredient in topical gels, such as Viru-Merz and Viru-Merz Serol, for the local application on the affected areas. This application method allows for targeted treatment, minimizing the risk of systemic side effects and enhancing the drug's effectiveness against the herpes simplex virus.
Mechanism of action
Tromantadine inhibits the early and late events in the?virus?replication cycle.It changes the?glycoproteins?of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents?uncoating?of the?virions.
Originator
Viru-Merz,Merz,W. Germany,1973
Manufacturing Process
Adamantane is first reacted with chloroacetyl chloride to give
chloroacetylaminoadamantane.
2.3 g Na (0.1 g-atom) were dissolved in 75 ml dimethylamino-ethanol. Then
the excess alcohol was distilled off completely and the sodium salt developed
was dried in a vacuum. After drying, the salt was dissolved in about 200 ml
xylene. To thissolution.22.8 g (0.1 mol) chloroacetylaminoadamantane were added, heated for 10 hours under reflux in a 250-ml round-bottomed flask
with a reflux cooler, and the sodium chloride developed subsequently filtered
off.
Next the xylene was distilled away, the liquid residue dissolved in about 80 ml
carbon tetrachloride and the hydrochloride precipitated through introduction of
hydrochloric acid gas. The hydrochloride was dissolved in about 100 ml
acetone and the solvent subsequently distilled away, whereby excess
hydrochloric acid passed over with it. This operation was repeated until no
excess acid was present.
A large excess of petroleum ether was added in a 500 ml three-necked flask
provided with a stirrer and reflux cooler, to a concentrated acetonic solution of
the hydrochloride and stirred for at least 1 hour, whereby the desired
substance was deposited in a crystalline form. Finally, the substance was
filtered away and dried in a desiccator. 14 g of the substance (15% of theory)
were obtained.
Therapeutic Function
Antiviral
Check Digit Verification of cas no
The CAS Registry Mumber 53783-83-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,8 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 53783-83:
(7*5)+(6*3)+(5*7)+(4*8)+(3*3)+(2*8)+(1*3)=148
148 % 10 = 8
So 53783-83-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)
53783-83-8Relevant articles and documents
COMPOUNDS CONTAINING AN ALICYCLIE STRUCTURE AND ANTI-TUMOR APPLICATION
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Paragraph 0041, (2014/03/21)
This invention relates with anti-tumor activities of new compounds containing an adamantyl group or analogs thereof. The invention also relates with the medication applications of anti-tumor and other diseases by this kind of compounds with the combination of S, P, T structures containing adamantyl group and the formation of stereoisomer, tautomers, prodrug, pharmaceutically acceptable salts, complex salts or solvates to their anticancer application and anticancer agents, which have the following general formula:
