5382-89-8Relevant articles and documents
Study of the Room-Temperature Synthesis of Oxime Ethers by using a Super Base
Kosmalski, Tomasz,Studzińska, Renata,Daniszewska, Natalia,Ullrich, Ma?gorzata,Sikora, Adam,Marsza??, Micha?,Modzelewska-Banachiewicz, Bo?ena
, p. 551 - 557 (2018/08/17)
In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base—pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2 min to 3 h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titled compounds was performed by using 1H NMR and 13C NMR spectroscopy as well as mass spectrometry. The presented method of synthesis for oxime ethers is environmentally friendly, because neither water cooling or heating of the reaction mixture/solvents (necessary for chromatographic purification) is required. The synthesis can be carried out very easily on a large scale.
Bioorthogonal oxime ligation of a Mo(CO)4(N-N) CO-releasing molecule (CORM) to a TGF β-binding peptide
Pfeiffer, Hendrik,Sowik, Thomas,Schatzschneider, Ulrich
supporting information, p. 17 - 24 (2013/06/27)
Carbon monoxide is now well-established as an endogenously produced gasotransmitter in humans. To utilizes its spectrum of biological activity for therapeutic purposes, solid storage forms such as metal carbonyl complexes have to be used for easy handling and targeted delivery to the body. Thus, in the present work, a [Mo(CO)4(bpyCH3,CHO)] complex with an aldehyde group in a peripheral position on the 2,2′-bipyridine (bpy) ligand was coupled to a bioactive transforming growth factor (TGF) β-targeting peptide N-terminally functionalized with aminoxy acetic acid using the bioorthogonal and catalyst-free oxime ligation. CO release studies with the myoglobin assay as well as UV/Vis and IR spectroscopy showed the molybdenum tetracarbonyl moiety to slowly liberate carbon monoxide upon incubation in buffer in the dark. In addition, photoactivation at 468 nm with a LED array resulted in a significantly accelerated release of carbon monoxide, thus establishing this peptide bioconjugate as a new photoactivatable CO-releasing molecule (PhotoCORM) with a red-shifted excitation wavelength for better tissue penetration.
COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE
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Page 85, (2010/02/09)
Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formula (1.4) or (1.5) wherein R, R and R are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
