53844-02-3Relevant articles and documents
Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites
Conway, Louis P.,Globisch, Daniel,L?hr, J.-Matthias,Lin, Weifeng,Vujasinovic, Miroslav
, p. 23232 - 23240 (2021)
The microbiome has a fundamental impact on the human host's physiology through the production of highly reactive compounds that can lead to disease development. One class of such compounds are carbonyl-containing metabolites, which are involved in diverse biochemical processes. Mass spectrometry is the method of choice for analysis of metabolites but carbonyls are analytically challenging. Herein, we have developed a new chemical biology tool using chemoselective modification to overcome analytical limitations. Two isotopic probes allow for the simultaneous and semi-quantitative analysis at the femtomole level as well as qualitative analysis at attomole quantities that allows for detection of more than 200 metabolites in human fecal, urine and plasma samples. This comprehensive mass spectrometric analysis enhances the scope of metabolomics-driven biomarker discovery. We anticipate that our chemical biology tool will be of general use in metabolomics analysis to obtain a better understanding of microbial interactions with the human host and disease development.
Organic amine linking agent with three carbon-carbon double bonds and preparation method thereof
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Paragraph 0030; 0066-0068; 0073, (2021/11/26)
The invention relates to the field of olefin organic amine linkers, and particularly discloses an organic amine linking agent with three carbon-carbon double bonds and a preparation method thereof. The invention discloses a chemical structural formula of
Method for catalyzing aldol self-condensation reaction of low-carbon aldehyde by acid alkali double-function ionic liquid
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Paragraph 0050-0052, (2018/03/01)
The invention relates to a method for catalyzing aldol self-condensation reaction of low-carbon aldehyde by acid alkali double-function ionic liquid. The method comprises the following steps: adding low-carbon aldehyde and an acid alkali double-function ionic liquid catalyst into a high-pressure kettle, reacting at 60 to 150 DEG C for 1 to 12 hours, and performing hydroxyaldehyde self-condensationreaction on the low-carbon aldehyde to obtain long-chain unsaturated aldehyde, wherein the acid alkali double-function ionic liquid is the acid alkali double-function ionic liquid with cation and anion containing acid and alkali groups correspondingly, or the novel acid alkali double-function ionic liquid with cation containing acid and alkali groups. The method is applied to aldol self-condensation reaction of n-butanal and n-pentanal and is mild in reaction condition, high in catalytic activity and high in selectivity; and the acid alkali double-function ionic liquid catalyst can be reused.