53853-65-9 Usage
Description
TERT-BUTANOL-1,1,1,3,3,3-D6, also known as tert-Butyl-1,1,1,3,3,3-d6 Alcohol, is an isotopically labeled research compound with the CAS number 53853-65-9. It is a derivative of tert-butyl alcohol, where six hydrogen atoms are replaced by deuterium atoms, making it a valuable tool in various research applications due to its unique isotopic properties.
Uses
Used in Research Applications:
TERT-BUTANOL-1,1,1,3,3,3-D6 is used as an isotopically labeled compound for various research purposes, such as studying the effects of deuterium substitution on chemical reactions, reaction mechanisms, and the behavior of molecules in different environments. The deuterium labeling allows researchers to track the compound's movement and interactions more accurately, providing valuable insights into the underlying processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TERT-BUTANOL-1,1,1,3,3,3-D6 is used as a research tool for the development of new drugs and the study of drug metabolism. The isotopic labeling can help researchers understand the metabolic pathways and potential side effects of drugs, as well as identify potential drug-drug interactions.
Used in Chemical Industry:
In the chemical industry, TERT-BUTANOL-1,1,1,3,3,3-D6 is used as a reference material for the calibration of analytical instruments and the development of new methods for the detection and quantification of deuterated compounds. Its unique isotopic properties make it an ideal candidate for these applications, contributing to the advancement of analytical chemistry techniques.
Used in Environmental Science:
In environmental science, TERT-BUTANOL-1,1,1,3,3,3-D6 can be used as a tracer compound to study the fate and transport of pollutants in the environment. The deuterium labeling allows for the differentiation between naturally occurring and anthropogenic sources of the compound, providing valuable information on the environmental impact of human activities.
Used in Material Science:
In material science, TERT-BUTANOL-1,1,1,3,3,3-D6 can be employed as a component in the synthesis of deuterated materials with unique properties, such as altered chemical reactivity or improved stability. The incorporation of deuterium into materials can lead to novel applications in various fields, including energy production, catalysis, and advanced materials development.
Check Digit Verification of cas no
The CAS Registry Mumber 53853-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,8,5 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 53853-65:
(7*5)+(6*3)+(5*8)+(4*5)+(3*3)+(2*6)+(1*5)=139
139 % 10 = 9
So 53853-65-9 is a valid CAS Registry Number.
53853-65-9Relevant articles and documents
Diphenylamino pyrimidine compound for inhibiting kinase activity
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Paragraph 0166; 0167; 0168; 0169; 0170; 0171, (2019/02/04)
The invention provides a diphenylamino pyrimidine compound for inhibiting the kinase activity, and particularly provides a medicinal composition of a substituted diphenylamino pyrimidine compound andapplication thereof. The compound is a compound as shown in a formula (I) in the specification, or pharmaceutically acceptable salt, prodrug, hydrate thereof or solvent compound, crystal form, N-oxideand various diastereomers thereof. The compound can be used for treating diseases which can be treated with JAK2 kinase inhibitors.
Deuterium isotope studies of the dehydration alcohols by reaction with triphenylphosphine-tetrachloromethane
Dabbagh,Franzus,Huang,Davis
, p. 949 - 960 (2007/10/02)
The reactions of 2-butanol, 2-butanol-2d1, erythro-2-butanol-3d1 (EB), 2-methyl-2-propranol (2M2P), and 1,1,1,3,3,3-hexadeuterio-2-methyl-2-propranol (HDMP), respectively, with CCL4, and Ph3P in a polar or non-polar solvent in the temperature range of 36-85°C was studied. For 2-butanol the fraction of dehydration products increased with temperature; the opposite temperature effect was observed for (2M2P). Dehydration was the dominant pathway for (2M2P) (85-95%) but substitution (of OH by Cl) was dominant for 2-butanol (75-95%). Deuterium retention in the butenes from the conversion of (EB) indicated that 98% or more of the dehydration followed an anti-elimination pathway, and there was a preference for Saytzeff elimination. An isotope effect for deuterium elimination (K(H)/k(D)) for the alkene-forming step for (EB) and (HDMP) was about 2.0, and neither temperature nor solvent polarity appeared to have an effect on (k(H)/k(D)) in the range investigated. Surprisingly, there was an isotope effect for the relative rate of the formation of alkyl halide from (EB) but not from (HDMP).
