540738-14-5Relevant articles and documents
Design, synthesis and photochemical properties of caged bile acids
Hirayama, Yuuki,Iwamura, Michiko,Furuta, Toshiaki
, p. 905 - 908 (2007/10/03)
Photolabile derivatives of bile acids (8-10 and 13) were synthesized via silver (I) oxide promoted selective etherification of 3α-hydroxyls. Quantitative production of the parent cholic acid was detected from the photolytic mixture of 3-NB-CA (8) in Tris buffered solution. Interestingly, the unexpectedly stable nitroso-hemiacetal intermediate (14) was detected when the photolysis was conducted in methanol. The enzymatic analysis using 7α-HSDH showed 8 and 9 could serve as caged bile acids that might be able to regulate certain biological processes upon UV irradiation.