54091-06-4

Basic information

• Product Name: 4-bromophenylchloromethyl sulfone
• Synonyms: 4-bromophenylchloromethyl sulfone;Chloromethyl(p-bromophenyl) sulfone;p-Bromophenyl(chloromethyl) sulfone;4-(CHLOROMETHYLSULFONYL)BROMOBENZENE;1-bromo-4-((chloromethyl)sulfonyl)benzene
• CAS NO: 54091-06-4
• Molecular Formula: C₇H₆BrClO₂S
• Molecular Weight: 269.54
• Mol File: 54091-06-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 381.5°Cat760mmHg
• Flash Point: 184.5°C
• Appearance: /
• Density: 1.697g/cm³
• Refractive Index: 1.646
• CAS DataBase Reference: 4-bromophenylchloromethyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromophenylchloromethyl sulfone(54091-06-4)
• EPA Substance Registry System: 4-bromophenylchloromethyl sulfone(54091-06-4)

Safety Data

• Hazardous Substances Data: 54091-06-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H10Br2Cl2O2S/c15-11-5-1-9(2-6-11)13(17)21(19,20)14(18)10-3-7-12(16)8-4-10/h1-8,13-14H

Upstream product

• 7569-24-6 4-chloromethanesulfonyl-aniline 
• 74-97-5 chlorobromomethane 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 710-24-7 4-acetamidobenzenesulfinic acid 
• 21506-06-9 acetic acid-(4-chloromethanesulfonyl-anilide) 

Relevant articles and documents

Lowering of 5-nitroimidazole's mutagenicity: Towards optimal antiparasitic pharmacophore

To improve the antiparasitic pharmacophore, 20 5-nitroimidazoles bearing an arylsulfonylmethyl group were prepared from commercial imidazoles. The antiparasitic activity of these molecules was assessed against Trichomonas vaginalis, the in vitro cytotoxicity was evaluated on human monocytes and the mutagenicity was determined by the Salmonella mutagenicity assay. All IC50 on T. vaginalis were below the one of metronidazole. The determination of the specificity indexes (SIs), defined as the ratios of the cytotoxic activity and the antitrichomonas activity, indicated that 11 derivatives had a SI over the one of metronidazole. Molecules, bearing an additional methyl group on the 2-position, showed a lower mutagenicity than metronidazole. Moreover, three derivatives were characterized by a low mutagenicity and an efficient antitrichomonas activity.