54113-41-6

Basic information

• Product Name: Methyl-4,5-dibromo-2-furoate
• Synonyms: Methyl-4,5-dibromo-2-furoate;4,5-Dibromofuran-2-carboxylicacid methyl ester;methyl 4,5-dibromofuran-2-carboxylate;Methyl 4,5-Dibromo-2-furancarboxylate
• CAS NO: 54113-41-6
• Molecular Formula: C₆H₄Br₂O₃
• Molecular Weight: 283.90216
• Mol File: 54113-41-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 56.0 to 60.0 °C
• Boiling Point: 110°C/0.8mmHg(lit.)
• Flash Point: 122.4°C
• Appearance: /
• Density: 1.992g/cm³
• Vapor Pressure: 0.0042mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: Methyl-4,5-dibromo-2-furoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-4,5-dibromo-2-furoate(54113-41-6)
• EPA Substance Registry System: Methyl-4,5-dibromo-2-furoate(54113-41-6)

Safety Data

• Hazardous Substances Data: 54113-41-6(Hazardous Substances Data)

Usage

Description

Methyl-4,5-dibromo-2-furoate is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds, particularly those with antibiotic and anticancer properties.

Uses

Used in Pharmaceutical Industry:
Methyl-4,5-dibromo-2-furoate is used as an intermediate in the synthesis of 4-Amino-2-furancarboxylic Acid (A609680) for the development of Proximicins. Proximicins A, B, and C are novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. These compounds exhibit potent bioactivity against various types of cancer and bacterial infections, making Methyl-4,5-dibromo-2-furoate a valuable component in the pharmaceutical industry for the development of new therapeutic agents.

InChI:InChI=1/C6H4Br2O3/c1-10-6(9)4-2-3(7)5(8)11-4/h2H,1H3

Upstream product

• 611-13-2 2-furoic acid methyl ester 
• 67-56-1 methanol 
• 2434-03-9 4,5-dibromo-2-furoic acid 
• 7732-18-5 water 
• 35900-96-0 4,5-dibromo-furan-2-carbonyl chloride 

Downstream Products

• 611-13-2 2-furoic acid methyl ester 
• 58235-80-6 4-bromofuran-2-carboxylic acid methyl ester 
• 2434-03-9 4,5-dibromo-2-furoic acid 
• 2528-02-1 methyl 3-bromo-2-methylfuran-5-carboxylate 
• 1217024-43-5 C₁₃H₁₁BrO₃ 
• 1217024-44-6 C₁₄H₁₃BrO₃ 
• 1333376-31-0 C₁₅H₁₆O₃ 
• 1333376-32-1 C₂₂H₂₃NO₂ 
• 1333376-30-9 C₁₄H₁₃BrO₃ 
• 1029061-05-9 methyl (5-((5-((4-hydroxyphenethyl)carbamoyl)furan-3-yl)carbamoyl)furan-3-yl)carbamate 

Relevant articles and documents

Design, Synthesis, and Fungicidal Evaluation of Novel Pyrazole-furan and Pyrazole-pyrrole Carboxamide as Succinate Dehydrogenase Inhibitors

The identification of novel succinate dehydrogenase (SDH) inhibitors represents one of the most attractive directions in the field of fungicide research and development. During our continuous efforts to pursue inhibitors belonging to this class, some structurally novel pyrazole-furan carboxamide and pyrazole-pyrrole carboxamide derivatives have been discovered via the introduction of scaffold hopping and bioisosterism to compound 1, a remarkably potent lead obtained by pharmacophore-based virtual screening. As a result of the evaluation against three destructive fungi, including Sclerotinia sclerotiorum, Rhizoctonia solani, and Pyricularia grisea, a majority of them displayed potent fungicidal activities. In particular, compounds 12I-i, 12III-f, and 12III-o exhibited excellent fungicidal activity against S. sclerotiorum and R. solani comparable to that of commercial SDHI thifluzamide and 1.

Substituted pyrazol ring derivative and application thereof

The invention discloses a substituted pyrazol ring derivative. The substituted pyrazol ring derivative is shown as the general formula I. The invention further provides an optical isomer or salt acceptable agriculturally of the substituted pyrazol ring derivative. The substituted pyrazol ring derivative, the optical isomer or the salt acceptable agriculturally can be used for preparing bactericides (including agricultural and gardening bactericides), and therefore prevention and control over agricultural and gardening fungi are achieved.

Efficient synthesis and biological evaluation of proximicins A, B and C

A quick and efficient synthesis and the biological evaluation of promising antitumor-antibiotics proximicins A, B and C are reported. The characteristic repetitive unit of these molecules, the methyl 4-Boc-aminofuran-2-carboxylate 15, was prepared in thre