54225-75-1

Basic information

• Product Name: (1R)-1-(4-ETHYLPHENYL)ETHANOL
• Synonyms: (1R)-1-(4-ETHYLPHENYL)ETHANOL
• CAS NO: 54225-75-1
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.21756
• Mol File: 54225-75-1.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1R)-1-(4-ETHYLPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-(4-ETHYLPHENYL)ETHANOL(54225-75-1)
• EPA Substance Registry System: (1R)-1-(4-ETHYLPHENYL)ETHANOL(54225-75-1)

Safety Data

• Hazardous Substances Data: 54225-75-1(Hazardous Substances Data)

Usage

Description

(1R)-1-(4-ETHYLPHENYL)ETHANOL, also known as chiral 4-ethylphenylethanol, is a chemical compound with the molecular formula C10H14O. It is an alcohol with a chiral center, meaning it has a specific spatial arrangement of atoms. (1R)-1-(4-ETHYLPHENYL)ETHANOL is characterized by its pleasant, floral odor and is used in various applications across different industries.

Uses

Used in Pharmaceutical and Agrochemical Industries:
(1R)-1-(4-ETHYLPHENYL)ETHANOL is used as a chiral building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique spatial arrangement of atoms makes it a valuable component in the development of new and innovative products in these sectors.
Used in Perfumery and Fragrance Industry:
(1R)-1-(4-ETHYLPHENYL)ETHANOL is used as a key ingredient in the production of perfumes and fragrances due to its pleasant, floral scent. This enhances the sensory experience of consumers and contributes to the overall appeal of these products.
Used in Flavor and Food Industry:
(1R)-1-(4-ETHYLPHENYL)ETHANOL has potential applications in the synthesis of flavoring agents. Its unique aroma profile can be utilized to create distinct and appealing flavors for various food and beverage products.
Used in Organic Synthesis:
(1R)-1-(4-ETHYLPHENYL)ETHANOL also serves as an intermediate in organic synthesis. Its versatile chemical properties allow it to be used in the production of a wide range of organic compounds, further expanding its utility across various industries.

Upstream product

• 33967-18-9 1-(4-ethylphenyl)ethanol 
• 105-05-5 1,4-diethylbenzene 
• 937-30-4 4-ethylacetophenone 
• 40307-11-7 1-ethyl-4-ethynylbenzene 
• 103966-60-5 1-(α-acetoxyethyl)-4-ethylbenzene 

Relevant articles and documents

One-Pot Chemoenzymatic Conversion of Alkynes to Chiral Amines

A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts of gold catalysts enabled the conversion of alkynes to ketones (>99%) after which a transaminase was used to catalyze the production of biologically valuable chiral amines in a good yield (up to 99%) and enantiomeric excess (>99%). A preparative scale synthesis of (S)-methylbenzylamine and (S)-4-methoxy-methylbenzylamine from its alkyne form gave a yield of 59 and 92%, respectively, withee> 99%.

Chiral Frustrated Lewis Pairs Catalyzed Highly Enantioselective Hydrosilylations of Ketones

A highly enantioselective Piers-type hydrosilylation of simple ketones was successfully realized using a chiral frustrated Lewis pair of tri-tert-butylphosphine and chiral diene-derived borane as catalyst. A wide range of optically active secondary alcohols were furnished in 80%—99% yields with 81%—97% ee's under mild reaction conditions.

Method for synthesizing chiral alcohol

The invention discloses a method for synthesizing chiral alcohol. The method comprises the following steps: adding alkyne, gold chloride [Au(L)Cl], a solvent methanol, and water into a reactor; carrying out reactions for 6 to 12 hours at a temperature of 110 DEG C, cooling to the room temperature; then adding sodium formate, water, and a transition metal rhodium catalyst Cp*RhCl[(R,R)-TsDPEN], carrying out reactions for 5 hours at a temperature of 30 to 40 DEG C, cooling to the room temperature, performing rotary evaporation to remove the solvent, and carrying out column separation to obtain the target compound. The provided method has the advantages that alkyne, which can be bought on the market or easily synthesized, is taken as the primary compound to synthesize chiral alcohol directly through cascade reactions, the intermediates do not need to be separated, the waste of time and solvent is avoided, and thus the provided method meets the requirements of green chemistry and has a wide development prospect.