5428-89-7 Usage
Description
5-Chloropyrimidin-2-amine is an organic compound with the molecular formula C4H4ClN3. It is a heterocyclic compound featuring a pyrimidine ring with a chlorine atom at the 5th position and an amino group at the 2nd position. 5-Chloropyrimidin-2-amine is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and reactivity.
Uses
Used in Pharmaceutical Research:
5-Chloropyrimidin-2-amine is used as a key intermediate in the synthesis of various biologically active compounds. Its ability to form JAK2 inhibitors makes it a valuable reagent for the development of treatments for myeloproliferative disorders, which are a group of blood cancers characterized by the overproduction of blood cells.
Additionally, 5-Chloropyrimidin-2-amine is used as a building block in the creation of SIRT2 inhibitors. These inhibitors are being investigated for their potential to treat Huntington's disease, a neurodegenerative disorder that affects muscle coordination and cognitive abilities.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 567, 1942 DOI: 10.1021/ja01255a030
Check Digit Verification of cas no
The CAS Registry Mumber 5428-89-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,2 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5428-89:
(6*5)+(5*4)+(4*2)+(3*8)+(2*8)+(1*9)=107
107 % 10 = 7
So 5428-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H4ClN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)
5428-89-7Relevant articles and documents
Hultquist bei Roblin,Winnek,English
, p. 570 (1942)
N-Chloro-N-methoxybenzenesulfonamide: A Chlorinating Reagent
Pu, Xiaoqiu,Li, Qingwei,Lu, Zehai,Yang, Xianjin
supporting information, p. 5937 - 5940 (2016/12/26)
A structurally simple and reactive chlorinating reagent, N-chloro-N-methoxybenzenesulfonamide, was conveniently and economically prepared in high yield. 1,3-Diketones, β-keto esters, benzoyl trifluoroacetones, phenols, anisoles, heteroarenes, and aromatic amines were successfully chlorinated, and the products were obtained in good to high yields.
HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA
-
, (2008/06/13)
This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.