54323-50-1Relevant articles and documents
Synthetic method for efficiently preparing folcisteine
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Paragraph 0031; 0034; 0037; 0039-0040, (2019/01/14)
The invention discloses a synthetic method for efficiently preparing folcisteine, belonging to the field of organic chemistry, comprising the following reaction steps: S1: reacting L-cysteine and 37%aqueous formaldehyde solution until L-cysteine is fully reacted to obtain L-thioproline; S2: directly adding an acetylation reagent to the system obtained by S1, and performing one-pot reaction untilL-thioproline is completely reacted; S3: adjusting the pH of the system obtained by S2 to 5-6, adding activated carbon for heating and decolorizing, cooling, adjusting the pH to 1-3, cooling and crystallizing to obtain folcisteine. The one-pot reaction is adopted for preparing acetyl thioproline, to avoid the post-treatment step of extracting intermediate thioproline after the first step reaction,shorten the process route, reduce the operation steps, and improve the work efficiency.
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads
West, Nicholas P.,Cergol, Katie M.,Xue, Millie,Randall, Elizabeth J.,Britton, Warwick J.,Payne, Richard J.
supporting information; scheme or table, p. 5166 - 5168 (2011/06/10)
The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.
