54395-37-8Relevant articles and documents
Preparation method of N - alkyl -4 -nitrophthalimide
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Paragraph 0049; 0051, (2021/10/27)
The invention discloses a preparation method of N - alkyl -4 -nitrophthalimide, which comprises the following steps of 1) mixing phthalic anhydride, alkyl aldehyde and inorganic amine, reacting under the action of hydrogen, cooling and crystallizing, and drying to obtain N -alkyl phthalimide. Step 2) The 1 alkylphthalimide obtained in step N -) is subjected to nitration reaction, and the product is purified and dried to obtain the N -alkyl -4 -nitrophthalimide. The alkyl aldehyde in step 1) is preferably an alkyl aldehyde of carbon 1 - 4. The preparation method has the advantages of wide raw material source, low price, simple process, easiness in large-scale production and the like. Through one-step synthesis, the reaction efficiency is high, the device is simple and easy to operate, and green and environment-friendly.
Method of constructing alpha-glucosidase inhibitor in three steps by taking imine as initial raw material
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Paragraph 0023-0050, (2019/03/08)
The invention relates to a method of constructing an alpha-glucosidase inhibitor in three steps by taking imine as an initial raw material. By taking (E)-N-butyl-1-(4-nitryl phenyl) methylenimine as areaction raw material, the alpha-glucosidase inhibitor is synthesized successfully through three reaction steps: carbonylation reaction, reduction reaction and sulfonation reaction. The method has the characteristics of being novel in synthetic means, simple to operate, excellent in yield and the like.
Carbonylation Access to Phthalimides Using Self-Sufficient Directing Group and Nucleophile
Ji, Fanghua,Li, Jianxiao,Li, Xianwei,Guo, Wei,Wu, Wanqing,Jiang, Huanfeng
, p. 104 - 112 (2018/02/19)
Herein we report a novel palladium-catalyzed oxidative carbonylation reaction for the synthesis of phthalimides with high atom- and step-economy. In our strategy, the imine and H2O, which are generated in situ from the condensation of aldehyde and amine, serve as self-sufficient directing group and nucleophile, respectively. This method provides rapid access to phthalimides starting from readily available materials in a one-pot manner. Various phthalimide derivatives are constructed efficiently, including medicinally and biologically active phthalimide-containing compounds.