544431-10-9Relevant articles and documents
Synthesis and insecticidal assessment of some innovative heterocycles incorporating a thiadiazole moiety against the cotton leafworm,: Spodoptera littoralis
Fadda, Ahmed A.,El Salam, M. Abd,Tawfik, Eman H.,Anwar,Etman
, p. 39773 - 39785 (2017)
New 2-cyano-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide (1) was utilized as a versatile precursor for the synthesis of various heterocycles, such as pyrrole, pyridine, coumarin, thiazole, pyrido[2′,3′:3,4]pyrazolo[5,1-c]triazine, triazolo[5,1-c]triazine, aminopyrazole, thiophene, 1,3-dithiolane, triazolo[1,5-a]pyrimidine and benzo[d]imidazole derivatives. The newly synthesized compounds were identified by IR, MS, 1H NMR, 13C NMR, DEPT, H-H COSY, HMBC, and HSQC. Representative compounds of the synthesized products were examined and estimated as insecticidal agents against the cotton leafworm, Spodoptera littoralis.
Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor α
Busch, Brett B.,Stevens Jr., William C.,Martin, Richard,Ordentlich, Peter,Zhou, Sihong,Sapp, Douglas W.,Horlick, Robert A.,Mohan, Raju
, p. 5593 - 5596 (2007/10/03)
The estrogen-related receptor α (ERRα) is an orphan receptor belonging to the nuclear receptor superfamily. The physiological role of ERRα has yet to be established primarily because of lack of a natural ligand. Herein, we describe the discovery of the fi