5448-38-4

Basic information

• Product Name: N-benzyl-2-methylbenzamide
• Synonyms: benzamide, 2-methyl-N-(phenylmethyl)-
• CAS NO: 5448-38-4
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.2857
• Mol File: 5448-38-4.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 404.7°C at 760 mmHg
• Flash Point: 244.1°C
• Density: 1.089g/cm³
• Vapor Pressure: 9.28E-07mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: N-benzyl-2-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-methylbenzamide(5448-38-4)
• EPA Substance Registry System: N-benzyl-2-methylbenzamide(5448-38-4)

Safety Data

• Hazardous Substances Data: 5448-38-4(Hazardous Substances Data)

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 100-46-9 benzylamine 
• 118-90-1 ortho-methylbenzoic acid 
• 529-19-1 2-Methylbenzonitrile 
• 100253-83-6 N-benzyl-N-nitrosopivalamide 
• 95-46-5 2-methylphenyl bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 615-37-2 ortho-methylphenyl iodide 
• 3991-75-1 N-(2-methylbenzoyl)imidazole 
• 201230-82-2 carbon monoxide 
• 529-20-4 2-methylphenyl aldehyde 
• 857275-38-8 3-(2-methylbenzyloxy)propan-1-ol 
• 364-20-5 2-methylbenzoyl fluoride 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 

Downstream Products

• 108779-09-5 2-benzyl-3-(4-methoxyphenyl)-2H-isoquinolin-1-one 
• 34497-14-8 1-oxo-3-phenyl-2-phenylmethyl-1,2-dihydroisoquinoline 
• 1403485-47-1 diethyl (2-methylphenyl)(benzylamino)methylphosphonate 
• 1612225-91-8 N-(tert-butylperoxy(phenyl)methyl)-2-methylbenzamide 
• 10254-11-2 N-(diphenylmethyl)-2-methylbenzamide 
• 80791-90-8 N-benzoyl-2-methylbenzamide 

Relevant articles and documents

Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides

We report how the rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides can be harnessed for the facile construction of amide bonds. This amidation reaction was found to be widely applicable to the synthesis of primary, secondary, and tertiary amides and was used as the key step in the synthesis of the lipid-lowering agent bezafibrate. The orthogonality and functional group tolerance of this approach was exemplified by the N-acylation of unprotected amino acids.

CuO-decorated magnetite-reduced graphene oxide: a robust and promising heterogeneous catalyst for the oxidative amidation of methylarenes in waterviabenzylic sp3C-H activation

A magnetite-reduced graphene oxide-supported CuO nanocomposite (rGO/Fe3O4-CuO) was preparedviaa facile chemical method and characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), Brunauer-Emmett-Teller (BET) analysis, vibrating-sample magnetometry (VSM), and thermogravimetric (TG) analysis. The catalytic activity of the rGO/Fe3O4-CuO nanocomposite was probed in the direct oxidative amidation reaction of methylarenes with free amines. Various aromatic and aliphatic amides were prepared efficiently at room temperature from cheap raw chemicals usingtert-butyl hydroperoxide (TBHP) as a “green” oxidant and low-toxicity TBAI in water. This method combines the oxidation of methylarenes and amide bond formation into a single operation. Moreover, the synthesized nanocomposites can be separated from the reaction mixtures using an external magnet and reused in six consecutive runs without a noticeable decrease in the catalytic activity.

An unprecedented cobalt-catalyzed selective aroylation of primary amines with aroyl peroxides

A novel and facile cobalt-catalyzed selective aroylation of primary amines with aroyl peroxides was developed for the synthesis of aryl amides. It was unprecedented that C[sbnd]N bond formation product was selectively generated without the common N[sbnd]O bond formation product. Aroyl peroxides act as the sole aroylation reagent without additional base or oxidant. The reactions proceeded under mild conditions and showed broad substrates scope with a series of primary amines and aroyl peroxides.