5451-41-2

Basic information

• Product Name: N-butyl-5H-purin-6-amine
• CAS NO: 5451-41-2
• Molecular Formula: C₉H₁₃N₅
• Molecular Weight: 191.233
• Mol File: 5451-41-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 300.4°C at 760 mmHg
• Flash Point: 135.5°C
• Density: 1.33g/cm³
• Vapor Pressure: 0.00112mmHg at 25°C
• Refractive Index: 1.678
• CAS DataBase Reference: N-butyl-5H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-5H-purin-6-amine(5451-41-2)
• EPA Substance Registry System: N-butyl-5H-purin-6-amine(5451-41-2)

Safety Data

• Hazardous Substances Data: 5451-41-2(Hazardous Substances Data)

Upstream product

• 109-73-9 N-butylamine 
• 50-66-8 6-(methylthio)-1H-purine 
• 68-94-0 1,7-dihydro-6H-purin-6-one 
• 50-44-2 6H-purine-6-thione 
• 10557-57-0 propylmagnesium iodide 
• 111098-24-9 Benzotriazol-1-ylmethyl-(9H-purin-6-yl)-amine 
• 19769-32-5 6-methylsulfonylpurine 
• 87-42-3 6-chloropurine 
• 50-66-8 6-methylthiopurine 
• 1229622-73-4 C₃₃H₃₅N₅O₂ 
• 66224-66-6 adenine 

Downstream Products

• 109-73-9 N-butylamine 
• 68-94-0 hypoxanthine 
• 23096-10-8 N₆-butyladenosine 

Relevant articles and documents

COMPOSITIONS AND METHODS USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable salts thereof, for the treatment and/or prevention of neurodegenerative disease and/or mitchonodrial disease including Parkinson's disease and Leigh's disease.

Convenient and efficient syntheses of N6-and N 4-substituted adenines and cytosines and their 2-deoxyribosides

Convenient and efficient methods of the synthesis of N6-and N4-substituted derivatives of adenine and cytosine and their 2-deoxyribosides were developed. The reactions of either unprotected nucleobases (adenine, cytosine) or unprotected 2-deoxyribosides with aryl or alkyl aldehydes give corresponding Schiff bases that can be reduced to the target title compounds with high overall yields. In the case of aryl aldehydes the imine derivatives are obtained in the presence of methoxides in methanol and reduced with sodium borohydride. The corresponding reactions with alkyl aldehydes require the use of acetic acid and borane dimethyl sulfide complex instead.

An efficient synthesis of substituted cytosines and purines under focused microwave irradiation

A rapid nucleophilic displacement reaction of 6-chloropurine, 2-amino-6-chloropurine and 5-bromocytosine with various nucleophiles under focused microwave irradiation is described. Using this method, the desired products were obtained with the yields up to 99% in?a?short reaction time.