5452-83-5

Basic information

• Product Name: 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE
• Synonyms: 2-(2-N-PIPERIDINOETHYL)PYRIDINE;1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE;2-[2-(piperidyl)ethyl]pyridine;2-[2-(1-piperidyl)ethyl]pyridine;2-(2-piperidinoethyl)pyridine;2-[2-(1-Piperidinyl)ethyl]pyridine
• CAS NO: 5452-83-5
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• EINECS: 226-696-8
• Mol File: 5452-83-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 83 °C
• Flash Point: 123.1°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.00614mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE(5452-83-5)
• EPA Substance Registry System: 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE(5452-83-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5452-83-5(Hazardous Substances Data)

Usage

Description

1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE is a chemical compound that features a piperidine ring with a 2-(2-pyridyl)ethyl group attached to it. 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE is frequently utilized as a building block in organic synthesis and pharmaceutical research due to its unique structure and potential interactions with biological targets.

Uses

Used in Pharmaceutical Research:
1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE is used as a key component in the development of drugs targeting the central nervous system. The reason for this application is that piperidine derivatives are known to possess analgesic and anesthetic properties, which are valuable for managing pain and inducing anesthesia.
Additionally, the presence of the 2-pyridyl group in the compound may enhance its ability to interact with specific receptors in the brain. This characteristic makes 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE a potentially valuable tool in medicinal chemistry research for the creation of new pharmaceuticals and biologically active molecules.

InChI:InChI=1/C12H18N2/c1-4-9-14(10-5-1)11-7-12-6-2-3-8-13-12/h2-3,6,8H,1,4-5,7,9-11H2

Upstream product

• 110-89-4 piperidine 
• 100-69-6 2-vinylpyridine 
• 3088-41-3 3-(piperidin-1-yl)propionitrile 
• 74-86-2 acetylene 
• 109-06-8 α-picoline 
• 103-74-2 2-(2-Hydroxyethyl)pyridine 

Downstream Products

• 14759-07-0 2-(2-Piperidinoethyl)piperidin 

Relevant articles and documents

Reversible C-N Bond Formation in the Zirconium-Catalyzed Intermolecular Hydroamination of 2-Vinylpyridine

The intermolecular hydroamination of alkenes with alkylamines has been a long-standing challenge in catalysis, partially due to the near-thermoneutral nature of this transformation. Consistent with this understanding, we report the direct observation of reversible C-N bond formation in hydroamination. A bis(ureate) zirconium complex catalyzed the intermolecular hydroamination of 2-vinylpyridine. Reversible C-N bond formation was characterized by variable-temperature NMR spectroscopy, and thermodynamic parameters were determined using van't Hoff plots. Isolated intermediates support an aza-Michael-addition mechanism. Sensitivity to steric bulk in the C-N bond forming step provided further evidence for the kinetically accessible but limited thermodynamic driving force for this transformation.

Aza-Michael-type addition reaction catalysed by a supported ionic liquid phase incorporating an anionic heteropoly acid

In this work, we have obtained substituted amines under mild conditions in good yields using the Aza-Michael-type addition of various amines to vinyl compounds catalysed by a supported ionic liquid incorporating an anionic heteropoly acid. Different catalysts, including Lewis acids, Br?nsted acids and heteropoly acids were investigated in which heteropoly acids having dual Br?nsted and Lewis acid characteristics were excellent catalysts. The ionic liquid incorporating a polytungstate anion supported on magnetic diatomaceous earth as a magnetically separable heterogeneous catalyst offered the best results in terms of yield. The solid nanocatalyst was easily removed with a magnet.

Photocatalyzed [2 + 2 + 2]-cycloaddition of nitriles with acetylene: An effective method for the synthesis of 2-pyridines under mild conditions

The photocatalyzed [2 + 2 + 2]-cycloaddition of nitriles with 2 equiv of acetylene to 2-pyridines can be carried out under mild conditions and represents a valuable extension to common synthetical methods. For the ideal wavelength range (350-500 nm), lamps as well as sunlight can be used. Working at room temperature and in organic solvents such as toluene or hexane as well as in water gives satisfying results in many cases. However, it is also possible to vary the solvent and the reaction temperature of the photocatalyzed synthesis and to choose, with respect to the specific substrate, specific requirements for this particular reaction and general requirements of the method. This simple and selective method derives its potential mainly from the large variety of applicable nitriles. Suitable substrates include (functionalized) aliphatic and aromatic nitriles as well as cyanamides derived from secondary amines.