5457-25-0

Basic information

• Product Name: ethyl 2-cyano-2-nitroso-acetate
• Synonyms: ethyl 2-cyano-2-nitroso-acetate
• CAS NO: 5457-25-0
• Molecular Formula: C₅H₆N₂O₃
• Molecular Weight: 142.11
• Mol File: 5457-25-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 198.5 °C at 760 mmHg
• Flash Point: 73.9 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0.358mmHg at 25°C
• Refractive Index: 1.495
• CAS DataBase Reference: ethyl 2-cyano-2-nitroso-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-cyano-2-nitroso-acetate(5457-25-0)
• EPA Substance Registry System: ethyl 2-cyano-2-nitroso-acetate(5457-25-0)

Safety Data

• Hazardous Substances Data: 5457-25-0(Hazardous Substances Data)

Usage

General Description

Ethyl 2-cyano-2-nitroso-acetate is a chemical compound with the molecular formula C5H6N2O4. It is a yellow crystalline solid that is commonly used as a reagent in organic synthesis. ethyl 2-cyano-2-nitroso-acetate is known for its versatile reactivity, and it can undergo various chemical reactions to produce a wide range of compounds. Ethyl 2-cyano-2-nitroso-acetate is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Its nitroso group makes it a valuable precursor for the synthesis of various nitroso compounds, which have applications in medicine and materials science. However, it should be handled with care, as it may be hazardous if not used properly.

InChI:InChI=1/C5H6N2O3/c1-2-10-5(8)4(3-6)7-9/h4H,2H2,1H3

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 37842-58-3 1-cyano-2-ethoxy-2-oxoethanaminium 4-methylbenzenesulfonate 

Relevant articles and documents

Synthesis process, intermediate and pharmaceutical process of 2, 4, 5-triamino-6-hydroxypyrimidine

The invention discloses a synthesis process of 2, 4, 5-triamino-6-hydroxypyrimidine, which comprises the following steps: 1) carrying out pressurized catalytic hydrogenation reaction on liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate to generate 2-amino and 2-cyanoacetic acid methyl ester/ethyl ester; (2) carrying out cyclization reaction on the 2-amino, 2-methyl cyanoacetate/ethyl cyanoacetate and free guanidine to generate 2, 4, 5-triamino-6-hydroxypyrimidine; wherein the liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate in the step 1) are generated by carrying out nitrosation reaction on methyl cyanoacetate/ethyl cyanoacetate and sodium nitrite. The invention also discloses intermediates 2-nitroso and 2-methyl cyanoacetate in the synthesis process, a synthesis process of the intermediates, and a pharmaceutical process taking the 2, 4, 5-triamino-6-hydroxypyrimidine as an intermediate. According to the present invention, the liquid new compounds such as 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate are subjected to the catalytic hydrogenation reaction, such that the problems of large water consumption and large wastewater yield in the 2, 4, 5-triamino-6-hydroxypyrimidine synthesis process can be solved, and the great economic significance and the great environmental protection significance are provided.