545882-54-0Relevant articles and documents
Synthesis of 1-amino-3-[(dihydroxyboryl)methyl]-cyclobutanecarboxylic acid as a potential therapy agent
Kabalka, George W.,Yao, Min-Liang
, p. 8280 - 8286 (2007/10/03)
A novel boronated aminocyclobutanecarboxylic acid (1) was synthesized for potential use in boron neutron capture therapy. Starting from the readily available 3-(bromomethyl)cyclobutanone ketal (4), several synthetic routes to 1 were evaluated. After sever
Synthesis of a Potential Boron Neutron Capture Therapy Agent: 1-Amino-cyclobutane-1-carboxylic Acid Bearing a Butylboronic Acid Side Chain
Kabalka, George W.,Yao, Min-Liang
, p. 2890 - 2893 (2007/10/03)
A novel boronated aminocyclobutanecarboxylic acid was synthesized for potential use in neutron capture therapy. The synthesis involves the preparation of tosylate 5, which was then converted to an amino acid using Bucherer-Strecker methodology. The molecu
