547-77-3

Basic information

• Product Name: 5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE
• Synonyms: ALLO THE;ALLOTETRAHYDROCORTISONE;5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE;5ALPHA-PREGNAN-3BETA,17ALPHA,21-TRIOL-11,20-DIONE;KENDALL'S COMPOUND 'G';REICHSTEIN'S SUBSTANCE 'D';WINTERSTEINER'S COMPOUND 'B';5A-pregnane-3A,17A,21-triol-11,20-*dione
• CAS NO: 547-77-3
• Molecular Formula: C₂₁H₃₂O₅
• Molecular Weight: 364.48
• EINECS: 208-936-3
• Mol File: 547-77-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 212-214°
• Boiling Point: 544.5°Cat760mmHg
• Flash Point: 297.1°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 4E-14mmHg at 25°C
• Refractive Index: 1.569
• PKA: 12.38±0.70(Predicted)
• CAS DataBase Reference: 5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE(547-77-3)
• EPA Substance Registry System: 5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE(547-77-3)

Safety Data

• Hazardous Substances Data: 547-77-3(Hazardous Substances Data)

Usage

Description

5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE, also known as Allotetrahydrocortisone, is a metabolite of Cortisone, a glucocorticoid and anti-inflammatory agent. It is a steroid compound with a unique molecular structure that contributes to its biological activity.
Used in Pharmaceutical Industry:
5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE is used as a pharmaceutical agent for its anti-inflammatory properties. It is utilized in the treatment of various inflammatory conditions due to its ability to modulate the immune response and reduce inflammation.
Used in Steroid Research:
5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE is used as a research compound in the field of steroid chemistry. It aids scientists in understanding the structure-activity relationships of steroid hormones and their potential applications in medicine.
Used in Hormone Replacement Therapy:
5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE is used as a hormone replacement therapy agent for individuals with adrenal insufficiency or other hormone-related disorders. It helps in maintaining hormonal balance and alleviating symptoms associated with these conditions.
Used in Cosmetic Industry:
5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE is used as an ingredient in cosmetic products for its anti-inflammatory and skin-soothing properties. It can be found in creams, lotions, and other skincare formulations to help reduce redness, irritation, and inflammation of the skin.

InChI:InChI=1/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,18,22-23,26H,3-11H2,1-2H3/t12-,13+,14-,15-,18+,19-,20-,21-/m0/s1

Upstream product

• 113752-81-1 3α,21-bis-formyloxy-11β,17-dihydroxy-5α-pregnan-20-one 
• 302-91-0 3α,11β,17α,21-tetrahydroxy-5α-pregnan-20-one 
• 1856-12-8 21-acetoxy-3β,17-dihydroxy-5α-pregnane-11,20-dione 
• 113455-07-5 3α,21-bis-formyloxy-17-hydroxy-5α-pregnane-11,20-dione 

Relevant articles and documents

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