54758-32-6Relevant articles and documents
Rhodium-Catalyzed Carbonylative Coupling of Alkyl Halides with Phenols under Low CO Pressure
Ai, Han-Jun,Li, Chong-Liang,Wang, Hai,Wu, Xiao-Feng
, p. 5147 - 5152 (2020/05/27)
A rhodium-catalyzed carbonylative transformation of alkyl halides under low pressure of CO has been developed. This robust catalyst system allows using phenols as the carbonylative coupling partner and, meanwhile, exhibits high functional group tolerance and good chemoselectivity. Substrates even with a large steric hindrance group or multiple reaction sites can be selectively converted into the desired products in good to excellent yields. A gram-scale experiment was performed and delivered an almost quantitative amount of the product. Control experiments were performed as well, and a possible reaction mechanism is proposed.
One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids
Lebedyeva, Iryna O.,Biswas, Suvendu,Goncalves, Kevin,Sileno, Sean M.,Jackson, Ashton R.,Patel, Kunal,Steel, Peter J.,Katritzky, Alan R.
, p. 11695 - 11698 (2014/10/15)
Monocarbonyl activation of 2,2-disubstituted malonic acids with benzotriazole leads to decarboxylation of one of the carboxy groups and formation of a C-H bond. Intermediate carbonyl benzotriazoles then readily acylate nucleophilic reagents and peptides resulting in libraries of conjugates and peptidomimetics.