547756-25-2Relevant articles and documents
P38 MAP kinase inhibitors. part 1: Design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold
Natarajan, Swaminathan R.,Wisnoski, David D.,Singh, Suresh B.,Stelmach, John E.,O'Neill, Edward A.,Schwartz, Cheryl D.,Thompson, Chris M.,Fitzgerald, Catherine E.,O'Keefe, Stephen J.,Kumar, Sanjeev,Hop, Cornelis E. C. A.,Zaller, Dennis M.,Schmatz, Dennis M.,Doherty, James B.
, p. 273 - 276 (2014/12/12)
A new class of p38 antagonists based on 3,4-dihydropyrido[3,2,-d]pyrimidine scaffold has been developed. These inhibitors exhibit unprecedented selectivity towards p38 over other very closely related kinases. Compounds 25, 33, and 34 were identified as be
