54901-54-1Relevant articles and documents
Synthesis of [thiazolium-2,2′-14C2]-SAR97276A from [14C]-thiourea
Herbert, John M.,Le Strat, Franck,Oumeddour, Delphine G.,Passey, Stephen C.,Taylor, Keith,Whitehead, David M.
, p. 89 - 92 (2011)
[thiazolium-2,2′-14C2]-SAR97276A, a bis(thiazolium) antimalarial development candidate, was synthesized from [ 14C]-thiourea with an overall radiochemical yield of 15%. The synthetic route involves a modified procedure for the synthesis of [ 14C]-sulfurol, also a key intermediate in thiamine synthesis, which was developed due to unlabelled chemistry proving irreproducible with the radiolabelled substrate. Copyright