54916-28-8

Basic information

• Product Name: 4-ACETYL-4'-METHOXYDIPHENYL ETHER
• Synonyms: 1-[4-(4-METHOXYPHENOXY)PHENYL]ETHAN-1-ONE;1-[4-(4-METHOXY-PHENOXY)-PHENYL]-ETHANONE;4-ACETYL-4'-METHOXYDIPHENYL ETHER;BUTTPARK 52\12-18;4-(4-Methoxyphenoxy)acetophenone;1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-on, 97%;1-[4-(4-Methoxyphenoxy)phenyl]-1-ethanone;1-[4-(4-Methoxyphenoxy)phenyl]ethan-1-one, 4-Acetyl-4'-methoxydiphenyl ether
• CAS NO: 54916-28-8
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• Mol File: 54916-28-8.mol
• Article Data: 32

Chemical Properties

• Melting Point: 56-58°C
• Boiling Point: 198-201°C 2mm
• Flash Point: 198-201°C/2mm
• Appearance: /
• Density: 1.123±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2115929
• CAS DataBase Reference: 4-ACETYL-4'-METHOXYDIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETYL-4'-METHOXYDIPHENYL ETHER(54916-28-8)
• EPA Substance Registry System: 4-ACETYL-4'-METHOXYDIPHENYL ETHER(54916-28-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• Hazardous Substances Data: 54916-28-8(Hazardous Substances Data)

Usage

General Description

4-ACETYL-4'-METHOXYDIPHENYL ETHER, also known as aMDE, is a chemical compound with the molecular formula C16H16O3. It is a derivative of diphenoxylic acid and belongs to the class of diphenyl ethers. 4-ACETYL-4'-METHOXYDIPHENYL ETHER is commonly used in organic synthesis and pharmaceutical research due to its diverse properties and potential applications. It has also been investigated for its potential therapeutic effects, particularly in the field of neuropharmacology. Additionally, aMDE has been studied for its antioxidant and antiviral activities, making it a valuable subject of research in the field of medicinal chemistry. Overall, 4-ACETYL-4'-METHOXYDIPHENYL ETHER is a versatile chemical with promising potential in various scientific and medical applications.

Upstream product

• 1655-69-2 1-methoxy-4-phenoxy-benzene 
• 75-36-5 acetyl chloride 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 150-76-5 4-methoxy-phenol 
• 99-90-1 para-bromoacetophenone 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 77-78-1 dimethyl sulfate 
• 1122-95-8 sodium 4-methoxyphenolate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 139-02-6 sodium phenoxide 
• 99-91-2 para-chloroacetophenone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 13329-40-3 4-Iodoacetophenone 

Downstream Products

• 1215-99-2 1-[4-(4-hydroxy-phenoxy)-phenyl]-ethanone 
• 94311-50-9 2-[4-(4-methoxyphenoxy)phenyl]-1-morpholin-4-yl-ethanethione 
• 116218-30-5 3-Dimethylamino-2-dimethylaminomethyl-1-[4-(4-methoxy-phenoxy)-phenyl]-propan-1-one; hydrochloride 
• 86896-98-2 4-methoxyphenyl 4-(hydroxyisopropyl)phenyl ether 
• 86431-73-4 4-methoxyphenyl 4-(chloroisopropyl)phenyl ether 
• 852631-12-0 [4-(4-methoxyphenoxy)phenyl]acetic acid methyl ester 
• 852631-17-5 [4-(4-methoxyphenoxy)phenyl]malonic dimethyl ester 
• 852631-21-1 5-[4-(4-methoxyphenoxy)phenyl]pyrimidine-2,4,6-trione 
• 852631-26-6 5-bromo-5-[4-(4-methoxyphenoxy)phenyl]pyrimidine-2,4,6-trione 
• 393796-68-4 5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-5-[4-(4-methoxy-phenoxy)-phenyl]-pyrimidine-2,4,6-trione 
• 92549-44-5 [4-(4-methoxyphenoxy)phenyl]acetic acid 
• 10181-93-8 4-(4-methoxyphenoxy)phenol 
• 257609-02-2 1-(4-(4-(benzyloxy)phenoxy)phenyl)ethan-1-one 
• 620633-63-8 1-(3-Fluoro-phenyl)-3-[4-(4-methoxy-phenoxy)-phenyl]-propane-1,3-dione 

Relevant articles and documents

Identification of an Oxalamide Ligand for Copper-Catalyzed C?O Couplings from a Pharmaceutical Compound Library

A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that is generally effective for copper-catalyzed C?O cross-couplings to prepare both biarylethers as well as phenols under mild conditions.

A diaryl ether compounds of the novel preparation method and application thereof

The invention relates to a diaryl ether compounds of the novel preparation method, in particular compound is added to the reactor in sequence 1, dimethyl sulfoxide, cesium carbonate, compound 2, stirring at room temperature 10 - 60 minutes; then placing the reaction temperature is set to 70 - 120 °C the pot of the oil bath, and incandescent lamp for irradiation, the course of the reaction by TLC detection, to be after the reaction, the reaction solution by filtration, extraction and column chromatography, to obtain the target compound, the completion of the diaryl ether compound preparation. The technical scheme of the present invention visible under light induction, does not add any transition metal catalyst and ligand firmly oxidation reducing agent, aryl halide with phenol derivatives in photocatalytic C - O cross-coupling reaction. Preparation of mild conditions, green, high efficiency, low cost, simple and convenient operation. The preparation of this compound is a biological, medical, in the field of organic synthesis in particular pharmaceutical synthesis of important synthetic intermediate.

Method for preparing diaryl ether compound

The invention relates to a novel preparation method of a diaryl ether compound. The novel preparation method specifically comprises the following steps: sequentially putting a derivative of benzene, dimethyl sulfoxide, cesium carbonate and a phenol derivative into a reactor, and carrying out stirring for 30-60 minutes at room temperature; putting the mixture into an oil bath pot of which the reaction temperature is set as 70-120 DEG C, lighting the mixture with an incandescent light bulb, detecting the reaction process with TLC (thin layer chromatography), after the reaction is completed, carrying out filtering on a reaction liquid, and carrying out extraction and column chromatography, so as to obtain a target compound and complete preparation of the diaryl ether compound. By adopting thetechnical scheme of the invention, under induction of visible light, without addition of any transition metal catalyst, ligand or photoredox agent, an aryl halide and a phenol derivative are subjected to a photocatalytic C-O cross coupling reaction. The preparation method is mild in condition, green, efficient, low in cost and simple and convenient in operation. The prepared compound is a significant synthesis intermediate in fields such as biologics, medicines and organic synthesis, particularly in medicine synthesis.