54924-33-3

Basic information

• Product Name: (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL
• Synonyms: (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL ;Albb-005737;a-(4-Fluorophenyl)-4-piperidinemethanol HCl;(4-fluorophenyl)-(4-piperidinyl)methanol;(4-fluorophenyl)-(4-piperidyl)methanol
• CAS NO: 54924-33-3
• Molecular Formula: C₁₂H₁₆FNO
• Molecular Weight: 209.2599432
• Mol File: 54924-33-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 254-255 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 333.5 °C at 760 mmHg
• Flash Point: 155.5 °C
• Appearance: /
• Density: 1.141g/cm³
• Vapor Pressure: 5.4E-05mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: 2-8°C
• PKA: 14.06±0.20(Predicted)
• CAS DataBase Reference: (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL(54924-33-3)
• EPA Substance Registry System: (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL(54924-33-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 54924-33-3(Hazardous Substances Data)

Usage

General Description

(4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL is a chemical compound that consists of a piperidine ring with a 4-fluoro-phenyl group and a methanol group attached. It is commonly used in research and pharmaceutical development as a building block in the synthesis of various drugs and bioactive molecules. (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL may have potential applications in the treatment of various neurological and psychiatric disorders due to its ability to interact with certain receptors and enzymes in the brain. Additionally, it may also have uses in the synthesis of novel chemical entities for drug discovery and development. However, as with all chemicals, (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANOL should be handled and used with caution, following proper safety protocols and guidelines.

InChI:InChI=1/C12H16FNO/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10/h1-4,10,12,14-15H,5-8H2

Upstream product

• 41538-36-7 4-(4-fluorobenzoyl)pyridine 

Downstream Products

• 92822-02-1 4-(4-fluorobenzyl)piperidine 
• 135256-97-2 1-(4-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-propoxy}-3-methoxy-phenyl)-ethanone 
• 478537-30-3 [1-(3-amino-3-phenyl-propyl)-piperidin-4-yl]-(4-fluoro-phenyl)-methanol 
• 124931-44-8 1-(4-fluorophenyl)-2-[4-[(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]-ethanone 
• 1600520-84-0 C₂₀H₂₃FN₂O₃ 

Relevant articles and documents

Synthesis, Calcium-Channel-Blocking Activity, and Antihypertensive Activity of 4-(Diarylmethyl)-1-piperidines and Structurally Related

A series of 4-(diarylmethyl)-1-piperidines and structurally related compounds were synthesized as calcium-channel blockers and antihypertensive agents.Compounds were evaluated for calcium-channel-blocking activity by determineng their ability to antagonize calcium-induced contractions of isolated rabbit aortic strips.The most potent compounds were those with fluoro substituents in the 3- and/or 4-positions of both rings of the diphenylmethyl group.Bis(4-fluorophenyl)acetonitrile analogue 79 was similar in potency to bis(4-fluorophenyl)methyl compound 1.The methylene analogue of 1 (78) and derivatives of 1 that contained a hydroxyl (76), carbamoyl (80), amino (81), or acetamido (82) substituent on the methyl group were less potent.In most cases substituents on the phenoxy ring, changes in the distance between the aryloxy group and the piperidine nitrogen, and the substitution of S, N(CH3), or CH2 for the oxygen atom of the aryloxy group had only a small to moderate effect on the potency.The best compounds in this series were more potent than verapamil, diltiazem, flunarizine, and lidoflazine, but were less potent than nifedipine.Compounds were evaluated for antihypertensive activity in spontaneusly hypertensive rats (SHR) at an oral dose of 30 mg/kg.Of the 55 compounds tested, only nine produced a statistically significant (p-1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (63), which produced a 35percent reduction in blood pressure and was similar in activity to nifedipine.At lower doses, however, 4--1-piperidine (93) was one of the most effective antihypertensive agents, producing reductions in blood pressure of 17 and 11percent at oral doses of 10 and 3 mg/kg, respectively; 63 was inactive at 10 mg/kg.