549503-44-8

Basic information

• Product Name: 3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine
• Synonyms: 3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine
• CAS NO: 549503-44-8
• Molecular Weight: 507.823
• Mol File: 549503-44-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine(549503-44-8)
• EPA Substance Registry System: 3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine(549503-44-8)

Safety Data

• Hazardous Substances Data: 549503-44-8(Hazardous Substances Data)

Upstream product

• 24241-18-7 2-amino-3,5-dibromopyrazine 
• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 106-41-2 4-bromo-phenol 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 

Downstream Products

• 1338221-07-0 N-[3,5-bis{4-(tert-butyldimethylsilyloxy)phenyl}pyrazin-2-yl]-2-[4-(tert-butyldimethylsilyloxy)phenyl]acetamide 
• 1338220-41-9 N-[3, 5-bis(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)acetamide 
• 549503-37-9 N-hexyl-3,5-bis(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine 
• 549503-38-0 {3,5-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pyrazin-2-yl}-dihexyl-amine 
• 549503-39-1 {3,5-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pyrazin-2-yl}-decyl-amine 

Relevant articles and documents

COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES

Coelenterazine analogs with different luminescence properties from conventional ones and coelenteramide analogs with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogs modified at the

Synthesis of 3,7-dihydroimidazo[1,2a]pyrazine-3-ones and their chemiluminescent properties

A series of 3,7-dihydroimidazo[1,2a]pyrazine-3-ones were prepared from 2-amino-3,5-dibromopyrazine. The concise synthesis of coelenterazine (5j), in three steps, 48% overall yield and >99% purity exemplifies the strategy. Further, the synthetic approach facilitated the regiospecific incorporation of carboxyalkyl linkers on the 3,7-dihydroimidazo[1,2a]pyrazine-3-one nucleus that are required for bioconjugation. Peroxymonocarbonate, an electrophilic oxidant, was used to initiate 'pseudo-flash' chemiluminescence from this class of molecules.