5498-83-9

Basic information

• Product Name: 2,5,8,11,14-Pentaoxahexadecan-16-amine
• Synonyms: 2,5,8,11,14-Pentaoxahexadecan-16-amine;3-(2-Chloroquinolin-3-yl)-1-phenylprop-2-en-1-one;MPEG5-NH2;m-PEG5-amine;(E)-3-(2-chloroquinolin-3-yl)-1-phenylprop-2-en-1-one;Methyl-PEG5-amine
• CAS NO: 5498-83-9
• Molecular Formula: C₁₁H₂₅NO₅
• Molecular Weight: 293.74
• EINECS: 208-663-6
• Mol File: 5498-83-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 465.6 °C at 760 mmHg
• Flash Point: 235.4 °C
• Appearance: /
• Density: 1.282 g/cm³
• Vapor Pressure: 0.000244mmHg at 25°C
• Refractive Index: 1.444
• Storage Temp.: -20°C
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 8.74±0.10(Predicted)
• CAS DataBase Reference: 2,5,8,11,14-Pentaoxahexadecan-16-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5,8,11,14-Pentaoxahexadecan-16-amine(5498-83-9)
• EPA Substance Registry System: 2,5,8,11,14-Pentaoxahexadecan-16-amine(5498-83-9)

Safety Data

• Hazardous Substances Data: 5498-83-9(Hazardous Substances Data)

Usage

Description

2,5,8,11,14-Pentaoxahexadecan-16-amine, also known as m-PEG5-amine, is a PEG linker containing an amino group with 5 PEG units. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), and other functional groups. The hydrophilic PEG spacer increases solubility in aqueous media, making it a versatile molecule for various applications.

Uses

Used in Bioconjugation:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a bioconjugation agent for the formation of stable covalent bonds between biomolecules and other molecules, such as drugs or imaging agents. The reactive amino group allows for easy attachment to target molecules, while the hydrophilic PEG spacer improves solubility and biocompatibility.
Used in Drug Delivery:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG spacer can enhance the circulation time of drugs in the body, while the reactive amino group allows for the attachment of drugs or other targeting moieties.
Used as a Crosslinker:
In the field of material science, 2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a crosslinker to connect and stabilize polymer chains, creating a network structure with enhanced mechanical properties and stability.
Used in PEG Hydrogel:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used as a building block in the formation of PEG hydrogels, which are versatile materials with applications in tissue engineering, drug delivery, and wound healing. The hydrophilic PEG spacer and reactive amino group contribute to the formation of a stable, hydrated network.
Used for Surface Functionalization:
2,5,8,11,14-Pentaoxahexadecan-16-amine is used for surface functionalization to introduce specific chemical functionalities or biological moieties onto various surfaces, such as nanoparticles, microparticles, or planar substrates. This can enhance the performance of these materials in applications like sensors, catalysts, or targeted drug delivery systems.

InChI:InChI=1/C11H25NO5/c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3-2-12/h2-12H2,1H3

Upstream product

• 89485-61-0 16-azido-2,5,8,11,14-pentaoxahexadecane 
• 23778-52-1 3,6,9,12,15-pentaoxahexadecanol 
• 80755-67-5 3,6,9,12,15-pentaoxahexadecyl tosylate 
• 62921-74-8 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate 
• 112-35-6 triethylene glucol monomethyl ether 

Downstream Products

• 92451-00-8 C₁₉H₃₂N₂O₁₀ 

Relevant articles and documents

Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors

CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.

ALKYNYL INDAZOLE DERIVATIVE AND USE THEREOF

The main object of the present invention is to provide a novel compound which has a VEGF receptor tyrosine kinase inhibitory activity and is useful as an active ingredient for the treatment of diseases accompanying angiogenesis or edema, for example, age-related macular degeneration or the like. The present invention includes, for example, an alkynyl indazole derivative represented by the following general formula (I), a pharmaceutical acceptable salt thereof, and a medicine containing thereof.