550-70-9

Basic information

• Product Name: TRIPROLIDINE HYDROCHLORIDE
• Synonyms: TRANS-2[3-(1-PYRROLIDINYL)-1-P-TOLYLPROPENYL]PYRIDINE HYDROCHLORIDE;TRIPROLIDINE HCL;TRANS-TRIPROLIDINE HYDROCHLORIDE;(E)-2-[1-(4-METHYLPHENYL)-3-(1-PYRROLIDINYL)-1-PROPENYL]PYRIDINE HYDROCHLORIDE;2-[(1E)-1-(4-Methylphenyl)-3-pyrrolizino-1-propenyl]pyridine·hydrochloride;Venen;295 C 51;Actidil
• CAS NO: 550-70-9
• Molecular Formula: C₁₉H₂₂N₂*ClH
• Molecular Weight: 314.85
• EINECS: 208-985-0
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 550-70-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 116-118 °C
• Boiling Point: 435.4°Cat760mmHg
• Flash Point: 217.1°C
• Appearance: /
• Density: 1.061g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TRIPROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIPROLIDINE HYDROCHLORIDE(550-70-9)
• EPA Substance Registry System: TRIPROLIDINE HYDROCHLORIDE(550-70-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: UT7658000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 550-70-9(Hazardous Substances Data)

Usage

Description

TRIPROLIDINE HYDROCHLORIDE is a hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. It is a histamine H1 receptor antagonist with antihistaminic and anticholinergic properties, making it a versatile pharmaceutical compound for various applications.

Uses

Used in Pharmaceutical Industry:
TRIPROLIDINE HYDROCHLORIDE is used as an antihistaminic agent for the treatment and prevention of symptoms associated with allergies. It is particularly effective in providing relief for conditions such as urticaria, rhinitis, and various pruritic skin disorders.
TRIPROLIDINE HYDROCHLORIDE is used as a histamine H1 receptor antagonist for the prevention and treatment of chronic muscle pain.
Additionally, TRIPROLIDINE HYDROCHLORIDE is used in combination with cold medicine to provide relief for flu-like symptoms, thanks to its anticholinergic properties.

Therapeutic Function

Antihistaminic

InChI:InChI=1/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

Upstream product

• 13573-69-8 (Z)-triprolidine 
• 486-12-4 triprolidine 

Downstream Products

• 114576-86-2 hydroxymethyl triprolidine 
• 191228-20-3 (E)-2-[3-(1-pyrrolodinio)-1-(p-tolyl)-1-propenyl]pyridinium tetrachlorocopper(II) 

Relevant articles and documents

A PROCESS FOR PREPARATION OF E-ISOMER OF 1-(4-METHYLPHENYL)- 1-(2-PYRID YL)-3-PYRROLIDINO PROP-1-ENE AND ACID ADDITION SALTS THEREOF

A process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3- pyrrolidinoprop-1-ene of Formula-I, and acid addition salts thereof, said process comprising; dehydrating 1-(4-methylphenyl)-l -(2-pyridyl)-3-pyrrolidinopropan-1-ol of Formula III followed by adding a base solution to obtain a mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, and washing said mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3- pyrrolidinoprop-1-ene with water to dissolve Z isomer and to obtain E-isomer of 1- (4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula I, which is substantially free from Z isomer.