5504-24-5

Basic information

• Product Name: 2-PHENYL-ACETAMIDINE
• Synonyms: Benzeneacetamidine;Phenylacetamidine;Benzeneethanimidamide;2-Phenyl-acetamidine ,95%;2-phenylacetimidamide
• CAS NO: 5504-24-5
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.18
• Mol File: 5504-24-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 62-63 °C
• Boiling Point: 243.1 °C at 760 mmHg
• Flash Point: 100.8 °C
• Appearance: /
• Density: 1.06
• Vapor Pressure: 0.0327mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.62±0.40(Predicted)
• CAS DataBase Reference: 2-PHENYL-ACETAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-ACETAMIDINE(5504-24-5)
• EPA Substance Registry System: 2-PHENYL-ACETAMIDINE(5504-24-5)

Safety Data

• Hazardous Substances Data: 5504-24-5(Hazardous Substances Data)

Usage

Description

2-PHENYL-ACETAMIDINE is an organic compound that serves as a valuable synthetic intermediate in the pharmaceutical industry. It is characterized by its amide functional group and aromatic ring, which contribute to its reactivity and potential applications in various chemical reactions and synthesis processes.

Uses

Used in Pharmaceutical Synthesis:
2-PHENYL-ACETAMIDINE is used as a synthetic intermediate for the development of non-nucleoside reverse transcriptase inhibitors (NNRTIs). These inhibitors play a crucial role in the treatment of HIV/AIDS by blocking the activity of the reverse transcriptase enzyme, which is essential for the replication of the virus.
Additionally, 2-PHENYL-ACETAMIDINE is utilized in the preparation of naltrexone-derived pyridoand pyrimidomorphinans. Naltrexone is an opioid antagonist used to treat opioid dependence and alcohol use disorder. The synthesis of novel naltrexone-derived compounds can potentially lead to the development of more effective therapies for these conditions.

InChI:InChI=1/C8H10N2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,9,10)

Upstream product

• 140-29-4 phenylacetonitrile 
• 10602-65-0 phenyl-thioacetic acid O-ethyl ester 
• 2510-30-7 3-Amino-4-phenylisoxazol-5-one 
• 4971-77-1 ethyl 2-phenylethanimidoate 
• 23589-80-2 3-benzyl-1,2,4-oxadiazol-5(4H)-one 
• 10034-85-2 hydrogen iodide 
• 7664-41-7 ammonia 
• 5442-34-2 ethyl 2-phenylacetimidate hydrochloride 
• 98-95-3 nitrobenzene 
• 62-53-3 aniline 
• 75-05-8 acetonitrile 

Downstream Products

• 124121-41-1 N,N,N'-tris-(4-nitro-benzenesulfenyl)-2-phenyl-acetamidine 
• 872826-79-4 4-amino-2-benzyl-pyrimidine-5-carbonitrile 
• 92580-36-4 (2-benzyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid ethyl ester 
• 49773-40-2 N-chloro-2-phenyl-acetamidine 
• 55365-66-7 N-(3,4-Dichlorstyrylsulfonyl)-phenylacetamidin 
• 79899-29-9 2-amino-3-phenyl-5-nitropyridine 
• 152971-58-9 (4,6-Dibenzyl-5H-[1,3,5,2]triazaphosphinin-2-yl)-dimethyl-amine 
• 7664-41-7 ammonia 
• 103-81-1 Benzeneacetamide 
• 188937-22-6 2-benzyl-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester 
• 68282-55-3 2-benzyl-1H-imidazole-4-carbaldehyde 
• 896933-66-7 2-benzyl-5-methyl-pyrimidine-4,6-diol 

Relevant articles and documents

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation

Based on the novel allosteric site of deoxyhypusine synthase (DHPS), two series of 30 novel 5-(2-methoxyphenoxy)-2-phenylpyrimidin-4-amine derivatives as DHPS inhibitors were designed and synthesized. Among them, compound8m, with the best DHPS inhibitory potency (IC50= 0.014 μM), exhibited excellent inhibition against melanoma cells, which was superior to that of GC7. Besides, molecular docking and molecular dynamics (MD) simulations further proved that compound8mwas tightly bound to the allosteric site of DHPS. Flow cytometric analysis and enzyme-linked immunosorbent assay (ELISA) showed that compound8mcould inhibit the intracellular reactive oxygen species (ROS) level. Furthermore, by western blot analysis, compound8meffectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. Moreover, both Transwell analysis and wound healing analysis showed that compound8mcould inhibit the invasion and migration of melanoma cells. In thein vivostudy, the tumor xenograft model showed that compound8meffectively inhibited melanoma development with low toxicity.

Novel pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT 2C receptor ligands for the treatment of obesity

Obesity is one of the most serious public health problems worldwide in the 21st century. Current therapeutic treatment for obesity is mostly focused on preventive measures involving dietary control and physical exercises in combination with anti-obesity m

Heterocyclic compounds

The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.