55077-30-0 Usage
Description
Aclatonium napadisilate is a bioactive compound that functions as a cholinergic agonist, making it a valuable therapeutic agent for the treatment of autoimmune diseases. Its cholinergic properties allow it to stimulate the parasympathetic nervous system, which can help alleviate symptoms associated with various autoimmune conditions.
Uses
Used in Pharmaceutical Industry:
Aclatonium napadisilate is used as a therapeutic agent for autoimmune diseases due to its cholinergic agonist properties. It helps in managing and alleviating symptoms associated with these conditions by stimulating the parasympathetic nervous system, providing relief and improving the quality of life for patients.
Used in Autoimmune Disease Treatment:
Aclatonium napadisilate is used as a treatment option for patients suffering from autoimmune diseases. Its cholinergic agonist action aids in regulating the immune system and reducing the severity of symptoms, making it a valuable addition to the arsenal of medications available for managing these complex health issues.
Originator
Abovis ,Toyama ,Japan ,1981
Manufacturing Process
5.2 g of bis(choline)-naphthalene-1,5-disulfonate was suspended in 30 ml of
acetonitrile, and 10 g of lactic acid anhydride diacetate was added thereto.
This mixture was refluxed for 3 hours. The resulting reaction mixture was
allowed to stand at room temperature while cooling to precipitate the desired
product crystals, which were collected by filtration. 5.5 g (76% yield) of the
desired product having a melting point of 189°C to 191°C were obtained.
Therapeutic Function
Cholinergic
Safety Profile
Poison by intravenous route.Moderately toxic by subcutaneous route. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx andSOx. A cholinergic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 55077-30-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,0,7 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 55077-30:
(7*5)+(6*5)+(5*0)+(4*7)+(3*7)+(2*3)+(1*0)=120
120 % 10 = 0
So 55077-30-0 is a valid CAS Registry Number.
InChI:InChI=1/2C10H20NO4.C10H8O6S2/c2*1-8(15-9(2)12)10(13)14-7-6-11(3,4)5;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16/h2*8H,6-7H2,1-5H3;1-6H,(H,11,12,13)(H,14,15,16)/q2*+1;/p-2
55077-30-0Relevant articles and documents
Industrial preparation method of aclatonium napadisilate
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Paragraph 0051-0053, (2019/11/13)
The invention discloses an industrial preparation method of aclatonium napadisilate. The industrial preparation method comprises the following steps that lactic acid reacts with acetic anhydride, chloroformate and N,N-dimethylethanolamine in sequence to obtain acetyllactylcholine, acetyllactylcholine is added with acid to be prepared into a salt and then separated, and a product reacts with 1,5-naphthalenedisulfonic acid dimethyl ester to obtain aclatonium napadisilate. The industrial preparation method has the advantages that aclatonium napadisilate is prepared by a ''mixed acid anhydride strategy'', and the use of a volatile highly corrosive reagent can be avoided; water can be used as a solvent for preparation of an intermediate, and the amount of an organic solvent can be avoided or reduced; a ''one-pot method'' can be adopted to prepare the intermediate to reduce unit operation; the solvent can be directly added for crystallization in the post-processing process of the preparationof a finished product to improve the purity of the product; and the reaction scale can be enlarged to more than ten kilograms.
