55100-33-9

Basic information

• Product Name: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE
• Synonyms: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE;N-METHYL-3,4,5-TRIMETHOXYBENZAMIDE
• CAS NO: 55100-33-9
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.24
• Mol File: 55100-33-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE(55100-33-9)
• EPA Substance Registry System: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE(55100-33-9)

Safety Data

• Hazardous Substances Data: 55100-33-9(Hazardous Substances Data)

Usage

Description

3,4,5-trimethoxy-N-methylbenzamide is a chemical compound with the molecular formula C12H17NO4. It is a derivative of benzamide, with three methoxy groups and a methyl group attached to the nitrogen atom. 3,4,5-trimethoxy-N-methylbenzamide is commonly used in medicinal chemistry and pharmaceutical research as a potential drug candidate for various therapeutic applications. The methoxy groups and the amide functionality in its molecular structure contribute to its potential pharmacological properties, making it an interesting compound for further investigation and development. Additionally, it may possess unique biological activities that could be beneficial for the treatment of certain diseases or medical conditions.

Uses

Used in Pharmaceutical Research:
3,4,5-trimethoxy-N-methylbenzamide is used as a potential drug candidate for various therapeutic applications in pharmaceutical research. Its unique molecular structure with methoxy and amide groups contributes to its potential pharmacological properties, making it a promising compound for the development of new drugs.
Used in Medicinal Chemistry:
3,4,5-trimethoxy-N-methylbenzamide is used in medicinal chemistry for the investigation and development of its potential biological activities. Its unique molecular structure may offer insights into the treatment of certain diseases or medical conditions, providing a valuable resource for the discovery of new therapeutic agents.

Upstream product

• 82463-70-5 2-bromo-3,4,5-trimethoxy-N-methylbenzamide 
• 67-64-1 acetone 
• 74-89-5 methylamine 
• 118-41-2 Eudesmic acid 
• 421-20-5 Methyl fluorosulfonate 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 23346-82-9 2-bromo-3,4,5-trimethoxybenzoic acid 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 3086-62-2 3,4,5-trimethoxybenzamide 
• 67-56-1 methanol 
• 39201-89-3 3,4,5-trimethoxybenzaldehyde oxime 

Downstream Products

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 18638-99-8 3,4,5-trimethoxybenzylamine 
• 82791-57-9 6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxy-phenyl)-2H-isoquinolin-3-one 
• 82463-70-5 2-bromo-3,4,5-trimethoxy-N-methylbenzamide 
• 58780-82-8 N-methyl-1-(3,4,5-trimethoxyphenyl)methanamine 

Relevant articles and documents

Rhodium-Catalyzed Electrooxidative C?H Olefination of Benzamides

Metal-catalyzed chelation-assisted C?H olefinations have emerged as powerful tools for the construction of functionalized alkenes. Herein, we describe the rhoda-electrocatalyzed C?H activation/alkenylation of arenes. The olefinations of challenging electron-poor benzamides were thus accomplished in a fully dehydrogenative fashion under electrochemical conditions, avoiding stoichiometric chemical oxidants, and with H2 as the only byproduct. This versatile alkenylation reaction also features broad substrate scope and used electricity as a green oxidant.

Tandem Transformation of Aldoximes to N-Methylated Amides Using Methanol

Tandem conversion of aldoximes to N-methylated amides with methanol in presence of a single Ru(II) catalyst is accomplished through the Ru(II)-mediated rearrangement followed by the reductive N-methylation. Employing this protocol, several aldoximes were directly transformed to the N-methylated amides using methanol. Kinetic experiments with H218O advocated that the aldoxime is acted as the nucleophile during the aldoxime to amide rearrangement process. Involvement of nitrile intermediate during this transformation is realized from the kinetic study. (Figure presented.).

Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol

An efficient synthesis of N-methylated amides using methanol in the presence of a ruthenium(II) catalyst is realized. Notably, applying this process, tandem C-methylation and N-methylation were achieved to synthesize α-methyl N-methylated amides. In addition, several kinetic studies and control experiments with the plausible intermediates were performed to understand this novel protocol. Furthermore, detailed computational studies were carried out to understand the mechanism of this transformation.